The concept of a random coil. Residual structure in peptides and denatured proteins.
Non-native states of proteins are of increasing interest because of their relevance to issues such as protein folding, translocation and stability. A framework for interpreting the wealth of experimental data for non-native states emerging from rapid advances in experimental techniques involves comp...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1996
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| _version_ | 1797087051518050304 |
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| author | Smith, L Fiebig, K Schwalbe, H Dobson, C |
| author_facet | Smith, L Fiebig, K Schwalbe, H Dobson, C |
| author_sort | Smith, L |
| collection | OXFORD |
| description | Non-native states of proteins are of increasing interest because of their relevance to issues such as protein folding, translocation and stability. A framework for interpreting the wealth of experimental data for non-native states emerging from rapid advances in experimental techniques involves comparison with a "random coll' state, which possesses no structure except that inherent in the local interactions. We review here the concept of a random coil, from its global to its local properties. In particular, we focus on the description of a random coil in terms of statistical distributions in psi, phi space. We show that such a model, in combination with experimental data, provides insight into the structural properties of polypeptide chains and has significance for understanding protein folding and for molecular design. |
| first_indexed | 2024-03-07T02:30:34Z |
| format | Journal article |
| id | oxford-uuid:a71a6505-67f7-4539-8117-26e1cf1298b7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:30:34Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:a71a6505-67f7-4539-8117-26e1cf1298b72022-03-27T02:52:11ZThe concept of a random coil. Residual structure in peptides and denatured proteins.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a71a6505-67f7-4539-8117-26e1cf1298b7EnglishSymplectic Elements at Oxford1996Smith, LFiebig, KSchwalbe, HDobson, CNon-native states of proteins are of increasing interest because of their relevance to issues such as protein folding, translocation and stability. A framework for interpreting the wealth of experimental data for non-native states emerging from rapid advances in experimental techniques involves comparison with a "random coll' state, which possesses no structure except that inherent in the local interactions. We review here the concept of a random coil, from its global to its local properties. In particular, we focus on the description of a random coil in terms of statistical distributions in psi, phi space. We show that such a model, in combination with experimental data, provides insight into the structural properties of polypeptide chains and has significance for understanding protein folding and for molecular design. |
| spellingShingle | Smith, L Fiebig, K Schwalbe, H Dobson, C The concept of a random coil. Residual structure in peptides and denatured proteins. |
| title | The concept of a random coil. Residual structure in peptides and denatured proteins. |
| title_full | The concept of a random coil. Residual structure in peptides and denatured proteins. |
| title_fullStr | The concept of a random coil. Residual structure in peptides and denatured proteins. |
| title_full_unstemmed | The concept of a random coil. Residual structure in peptides and denatured proteins. |
| title_short | The concept of a random coil. Residual structure in peptides and denatured proteins. |
| title_sort | concept of a random coil residual structure in peptides and denatured proteins |
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