Chest radiograph findings in childhood pneumonia cases From the multisite PERCH Study.
<h4>Background</h4> <p>Chest radiographs (CXRs) are frequently used to assess pneumonia cases. Variations in CXR appearances between epidemiological settings and their correlation with clinical signs are not well documented.</p> <h4>Methods</h4> <p>The Pneu...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2017
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| _version_ | 1826289549725138944 |
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| author | Fancourt, N Knoll, M Baggett, HC Brooks, WA Feikin, DR Hammitt, LL Howie, SRC Kotloff, KL Levine, OS Madhi, SA Murdoch, DR Scott, JAG Thea, DM Awori, JO Barger-Kamate, B Chipeta, J DeLuca, AN Diallo, M Driscoll, AJ Ebruke, BE Higdon, MM Jahan, Y Karron, RA Mahomed, N Moore, DP Nahar, K Naorat, S Ominde, MS Park, DE Prosperi, C Somwe, S Thamthitiwat, S Zaman, SMA Zeger, SL O'Brien, KL |
| author_facet | Fancourt, N Knoll, M Baggett, HC Brooks, WA Feikin, DR Hammitt, LL Howie, SRC Kotloff, KL Levine, OS Madhi, SA Murdoch, DR Scott, JAG Thea, DM Awori, JO Barger-Kamate, B Chipeta, J DeLuca, AN Diallo, M Driscoll, AJ Ebruke, BE Higdon, MM Jahan, Y Karron, RA Mahomed, N Moore, DP Nahar, K Naorat, S Ominde, MS Park, DE Prosperi, C Somwe, S Thamthitiwat, S Zaman, SMA Zeger, SL O'Brien, KL |
| author_sort | Fancourt, N |
| collection | OXFORD |
| description | <h4>Background</h4> <p>Chest radiographs (CXRs) are frequently used to assess pneumonia cases. Variations in CXR appearances between epidemiological settings and their correlation with clinical signs are not well documented.</p> <h4>Methods</h4> <p>The Pneumonia Etiology Research for Child Health project enrolled 4232 cases of hospitalized World Health Organization (WHO)–defined severe and very severe pneumonia from 9 sites in 7 countries (Bangladesh, the Gambia, Kenya, Mali, South Africa, Thailand, and Zambia). At admission, each case underwent a standardized assessment of clinical signs and pneumonia risk factors by trained health personnel, and a CXR was taken that was interpreted using the standardized WHO methodology. CXRs were categorized as abnormal (consolidation and/or other infiltrate), normal, or uninterpretable.</p> <h4>Results</h4> <p>CXRs were interpretable in 3587 (85%) cases, of which 1935 (54%) were abnormal (site range, 35%–64%). Cases with abnormal CXRs were more likely than those with normal CXRs to have hypoxemia (45% vs 26%), crackles (69% vs 62%), tachypnea (85% vs 80%), or fever (20% vs 16%) and less likely to have wheeze (30% vs 38%; all P < .05). CXR consolidation was associated with a higher case fatality ratio at 30-day follow-up (13.5%) compared to other infiltrate (4.7%) or normal (4.9%) CXRs.</p> <h4>Conclusions</h4> <p>Clinically diagnosed pneumonia cases with abnormal CXRs were more likely to have signs typically associated with pneumonia. However, CXR-normal cases were common, and clinical signs considered indicative of pneumonia were present in substantial proportions of these cases. CXR-consolidation cases represent a group with an increased likelihood of death at 30 days post-discharge.</p> |
| first_indexed | 2024-03-07T02:30:35Z |
| format | Journal article |
| id | oxford-uuid:a71ab742-722e-4d1b-966f-0a1c4870c174 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:30:35Z |
| publishDate | 2017 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:a71ab742-722e-4d1b-966f-0a1c4870c1742022-03-27T02:52:13ZChest radiograph findings in childhood pneumonia cases From the multisite PERCH Study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a71ab742-722e-4d1b-966f-0a1c4870c174EnglishSymplectic Elements at OxfordOxford University Press2017Fancourt, NKnoll, MBaggett, HCBrooks, WAFeikin, DRHammitt, LLHowie, SRCKotloff, KLLevine, OSMadhi, SAMurdoch, DRScott, JAGThea, DMAwori, JOBarger-Kamate, BChipeta, JDeLuca, ANDiallo, MDriscoll, AJEbruke, BEHigdon, MMJahan, YKarron, RAMahomed, NMoore, DPNahar, KNaorat, SOminde, MSPark, DEProsperi, CSomwe, SThamthitiwat, SZaman, SMAZeger, SLO'Brien, KL <h4>Background</h4> <p>Chest radiographs (CXRs) are frequently used to assess pneumonia cases. Variations in CXR appearances between epidemiological settings and their correlation with clinical signs are not well documented.</p> <h4>Methods</h4> <p>The Pneumonia Etiology Research for Child Health project enrolled 4232 cases of hospitalized World Health Organization (WHO)–defined severe and very severe pneumonia from 9 sites in 7 countries (Bangladesh, the Gambia, Kenya, Mali, South Africa, Thailand, and Zambia). At admission, each case underwent a standardized assessment of clinical signs and pneumonia risk factors by trained health personnel, and a CXR was taken that was interpreted using the standardized WHO methodology. CXRs were categorized as abnormal (consolidation and/or other infiltrate), normal, or uninterpretable.</p> <h4>Results</h4> <p>CXRs were interpretable in 3587 (85%) cases, of which 1935 (54%) were abnormal (site range, 35%–64%). Cases with abnormal CXRs were more likely than those with normal CXRs to have hypoxemia (45% vs 26%), crackles (69% vs 62%), tachypnea (85% vs 80%), or fever (20% vs 16%) and less likely to have wheeze (30% vs 38%; all P < .05). CXR consolidation was associated with a higher case fatality ratio at 30-day follow-up (13.5%) compared to other infiltrate (4.7%) or normal (4.9%) CXRs.</p> <h4>Conclusions</h4> <p>Clinically diagnosed pneumonia cases with abnormal CXRs were more likely to have signs typically associated with pneumonia. However, CXR-normal cases were common, and clinical signs considered indicative of pneumonia were present in substantial proportions of these cases. CXR-consolidation cases represent a group with an increased likelihood of death at 30 days post-discharge.</p> |
| spellingShingle | Fancourt, N Knoll, M Baggett, HC Brooks, WA Feikin, DR Hammitt, LL Howie, SRC Kotloff, KL Levine, OS Madhi, SA Murdoch, DR Scott, JAG Thea, DM Awori, JO Barger-Kamate, B Chipeta, J DeLuca, AN Diallo, M Driscoll, AJ Ebruke, BE Higdon, MM Jahan, Y Karron, RA Mahomed, N Moore, DP Nahar, K Naorat, S Ominde, MS Park, DE Prosperi, C Somwe, S Thamthitiwat, S Zaman, SMA Zeger, SL O'Brien, KL Chest radiograph findings in childhood pneumonia cases From the multisite PERCH Study. |
| title | Chest radiograph findings in childhood pneumonia cases From the multisite PERCH Study. |
| title_full | Chest radiograph findings in childhood pneumonia cases From the multisite PERCH Study. |
| title_fullStr | Chest radiograph findings in childhood pneumonia cases From the multisite PERCH Study. |
| title_full_unstemmed | Chest radiograph findings in childhood pneumonia cases From the multisite PERCH Study. |
| title_short | Chest radiograph findings in childhood pneumonia cases From the multisite PERCH Study. |
| title_sort | chest radiograph findings in childhood pneumonia cases from the multisite perch study |
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