Periodontitis in RA-the citrullinated enolase connection.
Autoimmunity in rheumatoid arthritis (RA) is characterized by an antibody response to citrullinated proteins. Two of the risk factors for RA-HLA-DRB1 shared epitope alleles and smoking-are also associated with periodontitis, which is largely, but not exclusively, caused by Porphyromonas gingivalis i...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2010
|
| _version_ | 1797087070570676224 |
|---|---|
| author | Lundberg, K Wegner, N Yucel-Lindberg, T Venables, P |
| author_facet | Lundberg, K Wegner, N Yucel-Lindberg, T Venables, P |
| author_sort | Lundberg, K |
| collection | OXFORD |
| description | Autoimmunity in rheumatoid arthritis (RA) is characterized by an antibody response to citrullinated proteins. Two of the risk factors for RA-HLA-DRB1 shared epitope alleles and smoking-are also associated with periodontitis, which is largely, but not exclusively, caused by Porphyromonas gingivalis infection. Furthermore, RA and periodontitis have a similar pathophysiology, characterized by destructive inflammation. The citrullination of proteins by P. gingivalis and the subsequent generation of autoantigens that drive autoimmunity in RA represents a possible causative link between these two diseases. Antibodies directed towards the immunodominant epitope of human citrullinated α-enolase cross-react with a conserved sequence on citrullinated P. gingivalis enolase. On the basis of this cross-reactivity, in this Perspectives article we explore the hypothesis of molecular mimicry in the etiology of RA, with citrullinated enolase as the specific antigen involved. |
| first_indexed | 2024-03-07T02:30:51Z |
| format | Journal article |
| id | oxford-uuid:a7301f40-e8fd-43fe-b042-260ee85a1ab9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:30:51Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:a7301f40-e8fd-43fe-b042-260ee85a1ab92022-03-27T02:52:49ZPeriodontitis in RA-the citrullinated enolase connection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a7301f40-e8fd-43fe-b042-260ee85a1ab9EnglishSymplectic Elements at Oxford2010Lundberg, KWegner, NYucel-Lindberg, TVenables, PAutoimmunity in rheumatoid arthritis (RA) is characterized by an antibody response to citrullinated proteins. Two of the risk factors for RA-HLA-DRB1 shared epitope alleles and smoking-are also associated with periodontitis, which is largely, but not exclusively, caused by Porphyromonas gingivalis infection. Furthermore, RA and periodontitis have a similar pathophysiology, characterized by destructive inflammation. The citrullination of proteins by P. gingivalis and the subsequent generation of autoantigens that drive autoimmunity in RA represents a possible causative link between these two diseases. Antibodies directed towards the immunodominant epitope of human citrullinated α-enolase cross-react with a conserved sequence on citrullinated P. gingivalis enolase. On the basis of this cross-reactivity, in this Perspectives article we explore the hypothesis of molecular mimicry in the etiology of RA, with citrullinated enolase as the specific antigen involved. |
| spellingShingle | Lundberg, K Wegner, N Yucel-Lindberg, T Venables, P Periodontitis in RA-the citrullinated enolase connection. |
| title | Periodontitis in RA-the citrullinated enolase connection. |
| title_full | Periodontitis in RA-the citrullinated enolase connection. |
| title_fullStr | Periodontitis in RA-the citrullinated enolase connection. |
| title_full_unstemmed | Periodontitis in RA-the citrullinated enolase connection. |
| title_short | Periodontitis in RA-the citrullinated enolase connection. |
| title_sort | periodontitis in ra the citrullinated enolase connection |
| work_keys_str_mv | AT lundbergk periodontitisinrathecitrullinatedenolaseconnection AT wegnern periodontitisinrathecitrullinatedenolaseconnection AT yucellindbergt periodontitisinrathecitrullinatedenolaseconnection AT venablesp periodontitisinrathecitrullinatedenolaseconnection |