Prevention of hypoxia-induced pulmonary hypertension and vascular remodelling by targeting endothelial tetrahydrobiopterin-dependent nitric oxide synthase regulation

Prevention of hypoxia-induced pulmonary hypertension and vascular remodelling by targeting endothelial tetrahydrobiopterin-dependent nitric oxide synthase regulation

Dades bibliogràfiques
Autors principals:	Khoo, J, Zhao, L, Alp, N, Bendall, J, Rockett, K, Wilkins, MR, Channon, K
Format:	Conference item
Publicat:	2005

Ítems similars

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
per: Khoo, J, et al.
Publicat: (2004)

Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.
per: Khoo, J, et al.
Publicat: (2005)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
per: Alp, N, et al.
Publicat: (2004)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
per: Alp, N, et al.
Publicat: (2004)

Tetrahydrobiopterin deficiency causes pulmonary hypertension: Effects on lung superoxide levels, hypoxic pulmonary vasoconstriction and vascular remodelling
per: Khoo, J, et al.
Publicat: (2004)

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
per: Channon, K
Publicat: (2004)

Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
per: Khoo, J, et al.
Publicat: (2005)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
per: Cai, S, et al.
Publicat: (2005)

Reduced levels of tetrahydrobiopterin in diabetic mouse model: Effects on endothelial function and nitric oxide (NO) synthase dimerisation
per: Cai, S, et al.
Publicat: (2004)

Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
per: Alp, N, et al.
Publicat: (2003)

Endothelial tetrahydrobiopterin regulates eNOS coupling/uncoupling independent of vascular disease: Insights from targeted transgenic models
per: Bendall, J, et al.
Publicat: (2004)

Tetrahydrobiopterin and nitric oxide synthase recouplers
per: Channon, KM
Publicat: (2020)

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
per: Alp, N, et al.
Publicat: (2003)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
per: Crabtree, M, et al.
Publicat: (2011)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
per: Crabtree, M, et al.
Publicat: (2011)

Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
per: Bendall, J, et al.
Publicat: (2005)

Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
per: Bendall, J, et al.
Publicat: (2004)

Tetrahydrobiopterin Prevents Lung Ischemia/reperfusion-Induced Uncoupling of Endothelial Nitric Oxide Synthase
per: Juni, R, et al.
Publicat: (2012)

Endothelial tetrahydrobiopterin (BH4) regulates eNOS coupling in vivo: Functional effects of BH4-eNOS stoichiometry in endothelial targeted transgenic mice
per: Bendall, J, et al.
Publicat: (2005)

Nitric oxide bioactivity in ApoE -/- mice is maintained by increased endothelial tetrahydrobiopterin synthesis via targeted GTP cyclohydrolase-1 over-expression
per: Alp, N, et al.
Publicat: (2003)

Differential Inhibition of Constitutive and Inducible Nitric Oxide Synthase in Vascular Endothelial Cells by Analogues of Tetrahydrobiopterin
per: Mueller Nicolas J, et al.
Publicat: (2002-11-01)

Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.
per: Crabtree, M, et al.
Publicat: (2013)

Tetrahydrobiopterin-dependent eNOS coupling determines vascular remodeling through accelerated endothelial regeneration
per: Ali, Z, et al.
Publicat: (2007)

5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling.
per: Antoniades, C, et al.
Publicat: (2006)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
per: Crabtree, M, et al.
Publicat: (2011)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
per: Crabtree, M, et al.
Publicat: (2011)

GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.
per: Cai, S, et al.
Publicat: (2002)

Tetrahydrobiopterin: a vascular redox target to improve endothelial function.
per: Channon, K
Publicat: (2012)

Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.
per: Ali, Z, et al.
Publicat: (2013)

Tetrahydrobiopterin (BH4) Improves Endothelial Cell Survival After Vascular Injury
per: Rinze, R, et al.
Publicat: (2008)

Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.
per: Crabtree, M, et al.
Publicat: (2009)

Statin treatment improves vascular redox state through a tetrahydrobiopterin-mediated re-coupling of endothelial nitric oxide synthase, in human atherosclerosis
per: Antoniades, C, et al.
Publicat: (2011)

Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling.
per: Antoniades, C, et al.
Publicat: (2011)

Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin- mediated endothelial nitric oxide synthase coupling
per: Antoniades, C, et al.
Publicat: (2011)

Adenovirus-mediated GTP cyclohydrolase I gene delivery augments tetrahydrobiopterin and restores nitric oxide synthase function in hyperglycaemic human aortic endothelial cells
per: Cai, S, et al.
Publicat: (2004)

Adenovirus-mediated GTP cyclohydrolase I gene delivery augments tetrahydrobiopterin and restores nitric oxide synthase function in hyperglycaemic human aortic endothelial cells
per: Cai, S, et al.
Publicat: (2004)

CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
per: Ali, Z, et al.
Publicat: (2008)

Increased endothelial tetrahydrobiopterin levels in GTPCH-transgenic mice
per: Alp, N, et al.
Publicat: (2002)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
per: Chuaiphichai, S, et al.
Publicat: (2014)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
per: Chuaiphichai, S, et al.
Publicat: (2014)