Maternal iron deficiency perturbs embryonic cardiovascular development in mice
Congenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental teratogens. Here we identify a potential teratogen...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Springer Nature
2021
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| _version_ | 1797087090944507904 |
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| author | Kalisch-Smith, J Ved, N Szumska, D Munro, J Troup, M Harris, S Rodriguez-Caro, H Jacquemot, A Miller, J Stuart, E Wolna, M Hardman, E Prin, F Lana-Elola, E Aoidi, R Fisher, E Tybulewicz, V Mohun, T Lakhal-Littleton, S De Val, S Giannoulatou, E Sparrow, DB |
| author_facet | Kalisch-Smith, J Ved, N Szumska, D Munro, J Troup, M Harris, S Rodriguez-Caro, H Jacquemot, A Miller, J Stuart, E Wolna, M Hardman, E Prin, F Lana-Elola, E Aoidi, R Fisher, E Tybulewicz, V Mohun, T Lakhal-Littleton, S De Val, S Giannoulatou, E Sparrow, DB |
| author_sort | Kalisch-Smith, J |
| collection | OXFORD |
| description | Congenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental teratogens. Here we identify a potential teratogen causing CHD in mice: maternal iron deficiency (ID). We show that maternal ID in mice causes severe cardiovascular defects in the offspring. These defects likely arise from increased retinoic acid signalling in ID embryos. The defects can be prevented by iron administration in early pregnancy. It has also been proposed that teratogen exposure may potentiate the effects of genetic predisposition to CHD through gene-environment interaction. Here we show that maternal ID increases the severity of heart and craniofacial defects in a mouse model of Down syndrome. It will be important to understand if the effects of maternal ID seen here in mice may have clinical implications for women. |
| first_indexed | 2024-03-07T02:31:09Z |
| format | Journal article |
| id | oxford-uuid:a748e329-3822-4211-bc9b-283eddc3f29d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:31:09Z |
| publishDate | 2021 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:a748e329-3822-4211-bc9b-283eddc3f29d2022-03-27T02:53:44ZMaternal iron deficiency perturbs embryonic cardiovascular development in miceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a748e329-3822-4211-bc9b-283eddc3f29dEnglishSymplectic ElementsSpringer Nature2021Kalisch-Smith, JVed, NSzumska, DMunro, JTroup, MHarris, SRodriguez-Caro, HJacquemot, AMiller, JStuart, EWolna, MHardman, EPrin, FLana-Elola, EAoidi, RFisher, ETybulewicz, VMohun, TLakhal-Littleton, SDe Val, SGiannoulatou, ESparrow, DBCongenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental teratogens. Here we identify a potential teratogen causing CHD in mice: maternal iron deficiency (ID). We show that maternal ID in mice causes severe cardiovascular defects in the offspring. These defects likely arise from increased retinoic acid signalling in ID embryos. The defects can be prevented by iron administration in early pregnancy. It has also been proposed that teratogen exposure may potentiate the effects of genetic predisposition to CHD through gene-environment interaction. Here we show that maternal ID increases the severity of heart and craniofacial defects in a mouse model of Down syndrome. It will be important to understand if the effects of maternal ID seen here in mice may have clinical implications for women. |
| spellingShingle | Kalisch-Smith, J Ved, N Szumska, D Munro, J Troup, M Harris, S Rodriguez-Caro, H Jacquemot, A Miller, J Stuart, E Wolna, M Hardman, E Prin, F Lana-Elola, E Aoidi, R Fisher, E Tybulewicz, V Mohun, T Lakhal-Littleton, S De Val, S Giannoulatou, E Sparrow, DB Maternal iron deficiency perturbs embryonic cardiovascular development in mice |
| title | Maternal iron deficiency perturbs embryonic cardiovascular development in mice |
| title_full | Maternal iron deficiency perturbs embryonic cardiovascular development in mice |
| title_fullStr | Maternal iron deficiency perturbs embryonic cardiovascular development in mice |
| title_full_unstemmed | Maternal iron deficiency perturbs embryonic cardiovascular development in mice |
| title_short | Maternal iron deficiency perturbs embryonic cardiovascular development in mice |
| title_sort | maternal iron deficiency perturbs embryonic cardiovascular development in mice |
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