The role of inhibition in human motor cortical plasticity.
Over recent years evidence from animal studies strongly suggests that a decrease in local inhibitory signaling is necessary for synaptic plasticity to occur. However, the role of GABAergic modulation in human motor plasticity is less well understood. Here, we summarize the techniques available to qu...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2014
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| _version_ | 1797087091143737344 |
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| author | Bachtiar, V Stagg, C |
| author_facet | Bachtiar, V Stagg, C |
| author_sort | Bachtiar, V |
| collection | OXFORD |
| description | Over recent years evidence from animal studies strongly suggests that a decrease in local inhibitory signaling is necessary for synaptic plasticity to occur. However, the role of GABAergic modulation in human motor plasticity is less well understood. Here, we summarize the techniques available to quantify GABA in humans, before reviewing the existing evidence for the role of inhibitory signaling in human motor plasticity. We discuss a number of important outstanding questions that remain before the role of GABAergic modulation in long-term plasticity in humans, such as that underpinning recovery after stroke, can be established. |
| first_indexed | 2024-03-07T02:31:10Z |
| format | Journal article |
| id | oxford-uuid:a7490334-23b1-4ed8-81c0-77bf3e99caaf |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:31:10Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:a7490334-23b1-4ed8-81c0-77bf3e99caaf2022-03-27T02:53:34ZThe role of inhibition in human motor cortical plasticity.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a7490334-23b1-4ed8-81c0-77bf3e99caafEnglishSymplectic Elements at OxfordElsevier2014Bachtiar, VStagg, COver recent years evidence from animal studies strongly suggests that a decrease in local inhibitory signaling is necessary for synaptic plasticity to occur. However, the role of GABAergic modulation in human motor plasticity is less well understood. Here, we summarize the techniques available to quantify GABA in humans, before reviewing the existing evidence for the role of inhibitory signaling in human motor plasticity. We discuss a number of important outstanding questions that remain before the role of GABAergic modulation in long-term plasticity in humans, such as that underpinning recovery after stroke, can be established. |
| spellingShingle | Bachtiar, V Stagg, C The role of inhibition in human motor cortical plasticity. |
| title | The role of inhibition in human motor cortical plasticity. |
| title_full | The role of inhibition in human motor cortical plasticity. |
| title_fullStr | The role of inhibition in human motor cortical plasticity. |
| title_full_unstemmed | The role of inhibition in human motor cortical plasticity. |
| title_short | The role of inhibition in human motor cortical plasticity. |
| title_sort | role of inhibition in human motor cortical plasticity |
| work_keys_str_mv | AT bachtiarv theroleofinhibitioninhumanmotorcorticalplasticity AT staggc theroleofinhibitioninhumanmotorcorticalplasticity AT bachtiarv roleofinhibitioninhumanmotorcorticalplasticity AT staggc roleofinhibitioninhumanmotorcorticalplasticity |