IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.

Polymorphisms in the gene encoding the transcription factor IRF5 that lead to higher mRNA expression are associated with many autoimmune diseases. Here we show that IRF5 expression in macrophages was reversibly induced by inflammatory stimuli and contributed to the plasticity of macrophage polarizat...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Krausgruber, T, Blazek, K, Smallie, T, Alzabin, S, Lockstone, H, Sahgal, N, Hussell, T, Feldmann, M, Udalova, I
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	2011

Míreanna comhchosúla

IRF5 PROMOTES INFLAMMATORY MACROPHAGE POLARIZATION AND TH1/TH17 RESPONSE
de réir: Krausgruber, T, et al.
Foilsithe / Cruthaithe: (2011)

IRF5 as a defining factor of M1 macrophage polarization
de réir: Krausgruber, T, et al.
Foilsithe / Cruthaithe: (2010)

Novel role of IRF5 in transcriptional inhibition of human IL-10 gene expression
de réir: Krausgruber, T, et al.
Foilsithe / Cruthaithe: (2011)

KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages
de réir: Eames, H, et al.
Foilsithe / Cruthaithe: (2012)

IRF5 is a specific marker of inflammatory macrophages in vivo.
de réir: Weiss, M, et al.
Foilsithe / Cruthaithe: (2013)

IRF5 Is a Specific Marker of Inflammatory Macrophages In Vivo
de réir: Miriam Weiss, et al.
Foilsithe / Cruthaithe: (2013-01-01)

IRF5 is required for late-phase TNF secretion by human dendritic cells.
de réir: Krausgruber, T, et al.
Foilsithe / Cruthaithe: (2010)

IRF5:RelA interaction targets inflammatory genes in macrophages.
de réir: Saliba, D, et al.
Foilsithe / Cruthaithe: (2014)

IRF5 controls macrophage-neutrophil axis in inflammation
de réir: Udalova, I
Foilsithe / Cruthaithe: (2014)

IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages
de réir: David G. Saliba, et al.
Foilsithe / Cruthaithe: (2014-09-01)

Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses
de réir: Jihyung Lee, et al.
Foilsithe / Cruthaithe: (2020-02-01)

Diverse mechanisms of IRF5 action in inflammatory responses
de réir: Khoyratty, T, et al.
Foilsithe / Cruthaithe: (2018)

Diverse mechanisms of IRF5 action in inflammatory responses
de réir: Khoyratty, T, et al.
Foilsithe / Cruthaithe: (2018)

IRF5 guides monocytes toward an inflammatory CD11c+ macrophage phenotype and promotes intestinal inflammation
de réir: Corbin, AL, et al.
Foilsithe / Cruthaithe: (2020)

Etanercept alleviates psoriasis by reducing the Th17/Treg ratio and promoting M2 polarization of macrophages
de réir: Xiaoqing Li, et al.
Foilsithe / Cruthaithe: (2022-12-01)

IRF4 is required for migration of CD4+ T cells to the intestine but not for Th2 and Th17 cell maintenance
de réir: Constantin Schmidt, et al.
Foilsithe / Cruthaithe: (2023-07-01)

M1 MACROPHAGES AND IRF5 EXACERBATE ATHEROSCLEROTIC DISEASE
de réir: Seneviratne, A, et al.
Foilsithe / Cruthaithe: (2013)

Th17/Treg balance and macrophage polarization ratio in lower extremity arteriosclerosis obliterans
de réir: Zhen-Zhen Li, et al.
Foilsithe / Cruthaithe: (2024-01-01)

IL-17 boosts proinflammatory outcome of antiviral response in human cells.
de réir: Ryzhakov, G, et al.
Foilsithe / Cruthaithe: (2011)

Incomplete response of inflammatory arthritis to TNF alpha blockade is associated with the Th17 pathway
de réir: Alzabin, S, et al.
Foilsithe / Cruthaithe: (2012)

Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway.
de réir: Alzabin, S, et al.
Foilsithe / Cruthaithe: (2012)

Identification of Th1-polarized Th17 cells: solving the problem
de réir: E. M. Kuklina, et al.
Foilsithe / Cruthaithe: (2023-06-01)

Markers of Th1 polarized Th17 cells (literature review)
de réir: E. M. Kuklina, et al.
Foilsithe / Cruthaithe: (2023-07-01)

IRF5 in defining inflammatory macrophages: studies in vitro and in vivo
de réir: Weiss, M
Foilsithe / Cruthaithe: (2015)

Increased Development of Th1, Th17, and Th1.17 Cells Under T1 Polarizing Conditions in Juvenile Idiopathic Arthritis
de réir: Anna E. Patrick, et al.
Foilsithe / Cruthaithe: (2022-07-01)

Role and mechanism of IRF9 in promoting the progression of rheumatoid arthritis by regulating macrophage polarization via PSMA5
de réir: Yue Guan, et al.
Foilsithe / Cruthaithe: (2024-08-01)

Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells.
de réir: Notley, C, et al.
Foilsithe / Cruthaithe: (2008)

Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases
de réir: Stefano Piazza, et al.
Foilsithe / Cruthaithe: (2022-11-01)

MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression
de réir: Aijun Jia, et al.
Foilsithe / Cruthaithe: (2017-01-01)

Artesunate suppresses Th17 response via inhibiting IRF4-mediated glycolysis and ameliorates Sjog̈ren’s syndrome
de réir: Fan Xiao, et al.
Foilsithe / Cruthaithe: (2022-08-01)

Th17 Response and Inflammatory Autoimmune Diseases
de réir: Janelle C. Waite, et al.
Foilsithe / Cruthaithe: (2012-01-01)

Effect of peripheral blood-derived mesenchymal stem cells on macrophage polarization and Th17/Treg balance in vitro
de réir: Rui Yang, et al.
Foilsithe / Cruthaithe: (2020-06-01)

IRF4 is Correlated with the Conversion to a Th17-Like Phenotype in Regulatory T Cells from the Malignant Pleural Effusion
de réir: Yu W, et al.
Foilsithe / Cruthaithe: (2021-09-01)

Clinical translation of anti-inflammatory effects of Prevotella histicola in Th1, Th2, and Th17 inflammation
de réir: Andrea Itano, et al.
Foilsithe / Cruthaithe: (2023-05-01)

Th1/Th2 paradigm extended: Macrophage polarization as an unappreciated pathogen-driven escape mechanism?
de réir: Eric eMuraille, et al.
Foilsithe / Cruthaithe: (2014-11-01)

Acidovorax temperans skews neutrophil maturation and polarizes Th17 cells to promote lung adenocarcinoma development
de réir: Joshua K. Stone, et al.
Foilsithe / Cruthaithe: (2024-04-01)

Adenosine Triphosphate Promotes Allergen-Induced Airway Inflammation and Th17 Cell Polarization in Neutrophilic Asthma
de réir: Fang Zhang, et al.
Foilsithe / Cruthaithe: (2017-01-01)

Novel Th17 Lymphocyte Populations, Th17.1 and PD1+Th17, are Increased in Takayasu Arteritis, and Both Th17 and Th17.1 Sub-Populations Associate with Active Disease
de réir: Singh K, et al.
Foilsithe / Cruthaithe: (2022-03-01)

IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation
de réir: Matija Hedl, et al.
Foilsithe / Cruthaithe: (2016-08-01)

Th17 Cells and Cytokines in Leprosy: Understanding the Immune Response and Polarization
de réir: Larissa Marchi Zaniolo, et al.
Foilsithe / Cruthaithe: (2023-10-01)