IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.

Polymorphisms in the gene encoding the transcription factor IRF5 that lead to higher mRNA expression are associated with many autoimmune diseases. Here we show that IRF5 expression in macrophages was reversibly induced by inflammatory stimuli and contributed to the plasticity of macrophage polarizat...

Полное описание

Библиографические подробности
Главные авторы:	Krausgruber, T, Blazek, K, Smallie, T, Alzabin, S, Lockstone, H, Sahgal, N, Hussell, T, Feldmann, M, Udalova, I
Формат:	Journal article
Язык:	English
Опубликовано:	2011

Схожие документы

IRF5 PROMOTES INFLAMMATORY MACROPHAGE POLARIZATION AND TH1/TH17 RESPONSE
по: Krausgruber, T, и др.
Опубликовано: (2011)

IRF5 as a defining factor of M1 macrophage polarization
по: Krausgruber, T, и др.
Опубликовано: (2010)

Novel role of IRF5 in transcriptional inhibition of human IL-10 gene expression
по: Krausgruber, T, и др.
Опубликовано: (2011)

KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages
по: Eames, H, и др.
Опубликовано: (2012)

IRF5 is a specific marker of inflammatory macrophages in vivo.
по: Weiss, M, и др.
Опубликовано: (2013)

IRF5 Is a Specific Marker of Inflammatory Macrophages In Vivo
по: Miriam Weiss, и др.
Опубликовано: (2013-01-01)

IRF5 is required for late-phase TNF secretion by human dendritic cells.
по: Krausgruber, T, и др.
Опубликовано: (2010)

IRF5:RelA interaction targets inflammatory genes in macrophages.
по: Saliba, D, и др.
Опубликовано: (2014)

IRF5 controls macrophage-neutrophil axis in inflammation
по: Udalova, I
Опубликовано: (2014)

IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages
по: David G. Saliba, и др.
Опубликовано: (2014-09-01)

Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses
по: Jihyung Lee, и др.
Опубликовано: (2020-02-01)

Diverse mechanisms of IRF5 action in inflammatory responses
по: Khoyratty, T, и др.
Опубликовано: (2018)

Diverse mechanisms of IRF5 action in inflammatory responses
по: Khoyratty, T, и др.
Опубликовано: (2018)

IRF5 guides monocytes toward an inflammatory CD11c+ macrophage phenotype and promotes intestinal inflammation
по: Corbin, AL, и др.
Опубликовано: (2020)

Etanercept alleviates psoriasis by reducing the Th17/Treg ratio and promoting M2 polarization of macrophages
по: Xiaoqing Li, и др.
Опубликовано: (2022-12-01)

IRF4 is required for migration of CD4+ T cells to the intestine but not for Th2 and Th17 cell maintenance
по: Constantin Schmidt, и др.
Опубликовано: (2023-07-01)

M1 MACROPHAGES AND IRF5 EXACERBATE ATHEROSCLEROTIC DISEASE
по: Seneviratne, A, и др.
Опубликовано: (2013)

Th17/Treg balance and macrophage polarization ratio in lower extremity arteriosclerosis obliterans
по: Zhen-Zhen Li, и др.
Опубликовано: (2024-01-01)

IL-17 boosts proinflammatory outcome of antiviral response in human cells.
по: Ryzhakov, G, и др.
Опубликовано: (2011)

Incomplete response of inflammatory arthritis to TNF alpha blockade is associated with the Th17 pathway
по: Alzabin, S, и др.
Опубликовано: (2012)

Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway.
по: Alzabin, S, и др.
Опубликовано: (2012)

Identification of Th1-polarized Th17 cells: solving the problem
по: E. M. Kuklina, и др.
Опубликовано: (2023-06-01)

Markers of Th1 polarized Th17 cells (literature review)
по: E. M. Kuklina, и др.
Опубликовано: (2023-07-01)

IRF5 in defining inflammatory macrophages: studies in vitro and in vivo
по: Weiss, M
Опубликовано: (2015)

Increased Development of Th1, Th17, and Th1.17 Cells Under T1 Polarizing Conditions in Juvenile Idiopathic Arthritis
по: Anna E. Patrick, и др.
Опубликовано: (2022-07-01)

Role and mechanism of IRF9 in promoting the progression of rheumatoid arthritis by regulating macrophage polarization via PSMA5
по: Yue Guan, и др.
Опубликовано: (2024-08-01)

Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells.
по: Notley, C, и др.
Опубликовано: (2008)

Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases
по: Stefano Piazza, и др.
Опубликовано: (2022-11-01)

MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression
по: Aijun Jia, и др.
Опубликовано: (2017-01-01)

Artesunate suppresses Th17 response via inhibiting IRF4-mediated glycolysis and ameliorates Sjog̈ren’s syndrome
по: Fan Xiao, и др.
Опубликовано: (2022-08-01)

Th17 Response and Inflammatory Autoimmune Diseases
по: Janelle C. Waite, и др.
Опубликовано: (2012-01-01)

Effect of peripheral blood-derived mesenchymal stem cells on macrophage polarization and Th17/Treg balance in vitro
по: Rui Yang, и др.
Опубликовано: (2020-06-01)

IRF4 is Correlated with the Conversion to a Th17-Like Phenotype in Regulatory T Cells from the Malignant Pleural Effusion
по: Yu W, и др.
Опубликовано: (2021-09-01)

Clinical translation of anti-inflammatory effects of Prevotella histicola in Th1, Th2, and Th17 inflammation
по: Andrea Itano, и др.
Опубликовано: (2023-05-01)

Th1/Th2 paradigm extended: Macrophage polarization as an unappreciated pathogen-driven escape mechanism?
по: Eric eMuraille, и др.
Опубликовано: (2014-11-01)

Acidovorax temperans skews neutrophil maturation and polarizes Th17 cells to promote lung adenocarcinoma development
по: Joshua K. Stone, и др.
Опубликовано: (2024-04-01)

Adenosine Triphosphate Promotes Allergen-Induced Airway Inflammation and Th17 Cell Polarization in Neutrophilic Asthma
по: Fang Zhang, и др.
Опубликовано: (2017-01-01)

Novel Th17 Lymphocyte Populations, Th17.1 and PD1+Th17, are Increased in Takayasu Arteritis, and Both Th17 and Th17.1 Sub-Populations Associate with Active Disease
по: Singh K, и др.
Опубликовано: (2022-03-01)

IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation
по: Matija Hedl, и др.
Опубликовано: (2016-08-01)

Th17 Cells and Cytokines in Leprosy: Understanding the Immune Response and Polarization
по: Larissa Marchi Zaniolo, и др.
Опубликовано: (2023-10-01)