D-amino acid oxidase is expressed in the ventral tegmental area and modulates cortical dopamine.

D-amino acid oxidase is expressed in the ventral tegmental area and modulates cortical dopamine.

D-amino acid oxidase (DAO, DAAO) degrades the NMDA receptor co-agonist D-serine, modulating D-serine levels and thence NMDA receptor function. DAO inhibitors are under development as a therapy for schizophrenia, a disorder involving both NMDA receptor and dopaminergic dysfunction. However, a direct...

Bibliografske podrobnosti
Main Authors:	Betts, J, Schweimer, J, Burnham, K, Burnet, P, Sharp, T, Harrison, P
Format:	Journal article
Jezik:	English
Izdano:	Frontiers Research Foundation 2014

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