Prion-like spreading of Alzheimer's disease within the brain's connectome

The prion hypothesis states that misfolded proteins can act as infectious agents that template the misfolding and aggregation of healthy proteins to transmit a disease. Increasing evidence suggests that pathological proteins in neurodegenerative diseases adopt prion-like mechanisms and spread across...

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Autori principali: Fornari, S, Schäfer, A, Jucker, M, Goriely, A, Kuhl, E
Natura: Journal article
Pubblicazione: Royal Society 2019