Prion-like spreading of Alzheimer's disease within the brain's connectome
The prion hypothesis states that misfolded proteins can act as infectious agents that template the misfolding and aggregation of healthy proteins to transmit a disease. Increasing evidence suggests that pathological proteins in neurodegenerative diseases adopt prion-like mechanisms and spread across...
المؤلفون الرئيسيون: | Fornari, S, Schäfer, A, Jucker, M, Goriely, A, Kuhl, E |
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التنسيق: | Journal article |
منشور في: |
Royal Society
2019
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مواد مشابهة
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Spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain and its connectome
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