RPA activates the XPF‐ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks

RPA activates the XPF‐ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks

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During replication‐coupled DNA interstrand crosslink (ICL) repair, the XPF‐ERCC1 endonuclease is required for the incisions that release, or “unhook”, ICLs, but the mechanism of ICL unhooking remains largely unknown. Incisions are triggered when the nascent leading strand of a replication fork strik...

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Détails bibliographiques
Auteurs principaux:	Abdullah, U, McGouran, J, Brolih, S, Ptchelkine, D, El-Sagheer, A, Brown, T, McHugh, P
Format:	Journal article
Publié:	EMBO Press 2017

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