Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells.
Previous studies have demonstrated that bispecific hybrid antibodies produced by cell-cell fusion or chemically conjugated heteroaggregates can direct cytotoxic T lymphocytes to kill target cells for which they have no intrinsic specificity, a phenomenon we call effector cell retargeting (ECR). Thes...
| Huvudupphovsmän: | , , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
1988
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| _version_ | 1826289614885748736 |
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| author | Gilliland, L Clark, MR Waldmann, H |
| author_facet | Gilliland, L Clark, MR Waldmann, H |
| author_sort | Gilliland, L |
| collection | OXFORD |
| description | Previous studies have demonstrated that bispecific hybrid antibodies produced by cell-cell fusion or chemically conjugated heteroaggregates can direct cytotoxic T lymphocytes to kill target cells for which they have no intrinsic specificity, a phenomenon we call effector cell retargeting (ECR). These studies used bispecific reagents with one specificity directed to CD3 or Ti on the effector cell and the other directed to a target cell antigen. To avoid the need to create different hybrid hybridomas for each target antigen we have developed a universal means to elicit ECR through the use of an antiglobulin step. We have constructed a bispecific hybrid antibody with dual specificity for CD3 and a rat immunoglobulin light chain allotype. This bispecific antibody could mediate ECR to a range of target cells, each coated with distinct surface-binding rat monoclonal antibodies. A particular advantage of targeting to surface-bound monoclonal antibodies is that all other available effector systems may also attack the same antibody-coated target cell. |
| first_indexed | 2024-03-07T02:31:34Z |
| format | Journal article |
| id | oxford-uuid:a7683b51-36eb-4101-82d3-8647717ca9f6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:31:34Z |
| publishDate | 1988 |
| record_format | dspace |
| spelling | oxford-uuid:a7683b51-36eb-4101-82d3-8647717ca9f62022-03-27T02:54:30ZUniversal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a7683b51-36eb-4101-82d3-8647717ca9f6EnglishSymplectic Elements at Oxford1988Gilliland, LClark, MRWaldmann, HPrevious studies have demonstrated that bispecific hybrid antibodies produced by cell-cell fusion or chemically conjugated heteroaggregates can direct cytotoxic T lymphocytes to kill target cells for which they have no intrinsic specificity, a phenomenon we call effector cell retargeting (ECR). These studies used bispecific reagents with one specificity directed to CD3 or Ti on the effector cell and the other directed to a target cell antigen. To avoid the need to create different hybrid hybridomas for each target antigen we have developed a universal means to elicit ECR through the use of an antiglobulin step. We have constructed a bispecific hybrid antibody with dual specificity for CD3 and a rat immunoglobulin light chain allotype. This bispecific antibody could mediate ECR to a range of target cells, each coated with distinct surface-binding rat monoclonal antibodies. A particular advantage of targeting to surface-bound monoclonal antibodies is that all other available effector systems may also attack the same antibody-coated target cell. |
| spellingShingle | Gilliland, L Clark, MR Waldmann, H Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells. |
| title | Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells. |
| title_full | Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells. |
| title_fullStr | Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells. |
| title_full_unstemmed | Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells. |
| title_short | Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells. |
| title_sort | universal bispecific antibody for targeting tumor cells for destruction by cytotoxic t cells |
| work_keys_str_mv | AT gillilandl universalbispecificantibodyfortargetingtumorcellsfordestructionbycytotoxictcells AT clarkmr universalbispecificantibodyfortargetingtumorcellsfordestructionbycytotoxictcells AT waldmannh universalbispecificantibodyfortargetingtumorcellsfordestructionbycytotoxictcells |