Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells.

Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells.

Previous studies have demonstrated that bispecific hybrid antibodies produced by cell-cell fusion or chemically conjugated heteroaggregates can direct cytotoxic T lymphocytes to kill target cells for which they have no intrinsic specificity, a phenomenon we call effector cell retargeting (ECR). Thes...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Gilliland, L, Clark, MR, Waldmann, H
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	1988

Antzeko izenburuak

T-cell killing of target cells induced by hybrid antibodies: comparison of two bispecific monoclonal antibodies.
nork: Clark, MR, et al.
Argitaratua: (1987)

Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene.
nork: Shalaby, MR, et al.
Argitaratua: (1992)

Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies
nork: Freedman, J, et al.
Argitaratua: (2017)

Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies
nork: Joshua D Freedman, et al.
Argitaratua: (2017-06-01)

Bispecific antibody-activated T cells enhance NK cell-mediated antibody-dependent cellular cytotoxicity
nork: Zhaoming Wang, et al.
Argitaratua: (2021-12-01)

THE POTENTIAL OF HYBRID ANTIBODIES SECRETED BY HYBRID-HYBRIDOMAS IN TUMOR-THERAPY
nork: Clark, M, et al.
Argitaratua: (1987)

The role of calcium in the destruction of target cells by cytotoxic T cells
nork: Allbritton, Nancy L. (Nancy Lynn)
Argitaratua: (2005)

Safety Profiling of Tumor-targeted T Cell–Bispecific Antibodies with Alveolus Lung- and Colon-on-Chip
nork: S. Kerns, et al.
Argitaratua: (2023-01-01)

Harnessing the cytotoxic granule exocytosis to augment the efficacy of T-cell-engaging bispecific antibody therapy
nork: Mika Casey, et al.
Argitaratua: (2024-01-01)

697 Tumor-targeted CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors
nork: Gregory Moore, et al.
Argitaratua: (2020-11-01)

Bispecific antibody-targeted T-cell therapy for acute myeloid leukemia
nork: Ewa Kubicka, et al.
Argitaratua: (2022-11-01)

Therapeutic Bispecific T-Cell Engager Antibody Targeting the Transferrin Receptor
nork: Mingpeng Fu, et al.
Argitaratua: (2019-06-01)

Characterization of a novel bispecific antibody targeting tissue factor-positive tumors with T cell engagement
nork: Zhidi Pan, et al.
Argitaratua: (2022-04-01)

Development of a bispecific antibody targeting PD-L1 and TIGIT with optimal cytotoxicity
nork: Zhenwei Zhong, et al.
Argitaratua: (2022-10-01)

Targeting tumor vasculature to improve antitumor activity of T cells armed ex vivo with T cell engaging bispecific antibody
nork: Madelyn Espinosa-Cotton, et al.
Argitaratua: (2023-03-01)

Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies
nork: S Jordan Kerns, et al.
Argitaratua: (2021-08-01)

Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes.
nork: Hale, G, et al.
Argitaratua: (1985)

Comparative Analysis of Bispecific Antibody and Streptavidin-Targeted Radioimmunotherapy for B-cell Cancers
nork: Green, Damian J., et al.
Argitaratua: (2020)

Editorial: Bispecific Antibodies for T-Cell Based Immunotherapy
nork: Brian H. Santich, et al.
Argitaratua: (2020-12-01)

Hybrid antibodies for therapy.
nork: Clark, M, et al.
Argitaratua: (1988)

Bispecific, T-Cell-Recruiting Antibodies in B-Cell Malignancies
nork: Margaux Lejeune, et al.
Argitaratua: (2020-05-01)

Bispecific antibodies in indolent B-cell lymphomas
nork: Vivek S. Radhakrishnan, et al.
Argitaratua: (2024-01-01)

Targeting T cells with tetravalent bispecific antibodies for the treatment of graft-versus-host disease
nork: Madelyn Espinosa-Cotton, et al.
Argitaratua: (2025-01-01)

Recent advances of bispecific antibodies in solid tumors
nork: Shengnan Yu, et al.
Argitaratua: (2017-09-01)

Bispecific T cell engager (BiTE®) antibody constructs can mediate bystander tumor cell killing.
nork: Sandra L Ross, et al.
Argitaratua: (2017-01-01)

Modulating tumor infiltrating myeloid cells to enhance bispecific antibody-driven T cell infiltration and anti-tumor response
nork: Jeong A. Park, et al.
Argitaratua: (2021-09-01)

Engineering of dendritic cell bispecific extracellular vesicles for tumor-targeting immunotherapy
nork: Fang Xu, et al.
Argitaratua: (2023-10-01)

Dual Targeting of Tumor Cells with Bispecific Single-Chain Fv-Immunoliposomes
nork: Katharina Mack, et al.
Argitaratua: (2012-07-01)

Co-targeting cancer stem-like cells and bulk cancer cells with a bispecific antibody
nork: Shi Hu
Argitaratua: (2017-05-01)

Bispecific antibody targets and therapies in multiple myeloma
nork: Matthew Rees, et al.
Argitaratua: (2024-10-01)

Dual-target Bridging ELISA for Bispecific Antibodies
nork: Min Pei, et al.
Argitaratua: (2022-10-01)

T-cell stimulating vaccines empower CD3 bispecific antibody therapy in solid tumors
nork: Jim Middelburg, et al.
Argitaratua: (2024-01-01)

A novel asymmetrical anti-HER2/CD3 bispecific antibody exhibits potent cytotoxicity for HER2-positive tumor cells
nork: Shengnan Yu, et al.
Argitaratua: (2019-08-01)

Blocking of cytotoxic T cell function by monoclonal antibodies against the CD45 antigen (T200/leukocyte-common antigen).
nork: Tighe, H, et al.
Argitaratua: (1987)

Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies
nork: Christian Klein, et al.
Argitaratua: (2021-07-01)

698 PD-L1 targeted CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors
nork: Jing Qi, et al.
Argitaratua: (2021-11-01)

Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy
nork: Amelia C. McCue, et al.
Argitaratua: (2024-12-01)

Overcoming tumor heterogeneity by ex vivo arming of T cells using multiple bispecific antibodies
nork: Nai-Kong V Cheung, et al.
Argitaratua: (2022-01-01)

A Novel T Cell-Engaging Bispecific Antibody for Treating Mesothelin-Positive Solid Tumors
nork: Aerin Yoon, et al.
Argitaratua: (2020-03-01)

The potential of hybrid antibodies secreted by hybrid-hybridomas in tumour therapy.
nork: Clark, M, et al.
Argitaratua: (1988)