Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells.

Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells.

Previous studies have demonstrated that bispecific hybrid antibodies produced by cell-cell fusion or chemically conjugated heteroaggregates can direct cytotoxic T lymphocytes to kill target cells for which they have no intrinsic specificity, a phenomenon we call effector cell retargeting (ECR). Thes...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Gilliland, L, Clark, MR, Waldmann, H
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	1988

समान संसाधन

T-cell killing of target cells induced by hybrid antibodies: comparison of two bispecific monoclonal antibodies.
द्वारा: Clark, MR, और अन्य
प्रकाशित: (1987)

Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene.
द्वारा: Shalaby, MR, और अन्य
प्रकाशित: (1992)

Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies
द्वारा: Freedman, J, और अन्य
प्रकाशित: (2017)

Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies
द्वारा: Joshua D Freedman, और अन्य
प्रकाशित: (2017-06-01)

Bispecific antibody-activated T cells enhance NK cell-mediated antibody-dependent cellular cytotoxicity
द्वारा: Zhaoming Wang, और अन्य
प्रकाशित: (2021-12-01)

THE POTENTIAL OF HYBRID ANTIBODIES SECRETED BY HYBRID-HYBRIDOMAS IN TUMOR-THERAPY
द्वारा: Clark, M, और अन्य
प्रकाशित: (1987)

The role of calcium in the destruction of target cells by cytotoxic T cells
द्वारा: Allbritton, Nancy L. (Nancy Lynn)
प्रकाशित: (2005)

Safety Profiling of Tumor-targeted T Cell–Bispecific Antibodies with Alveolus Lung- and Colon-on-Chip
द्वारा: S. Kerns, और अन्य
प्रकाशित: (2023-01-01)

Harnessing the cytotoxic granule exocytosis to augment the efficacy of T-cell-engaging bispecific antibody therapy
द्वारा: Mika Casey, और अन्य
प्रकाशित: (2024-01-01)

697 Tumor-targeted CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors
द्वारा: Gregory Moore, और अन्य
प्रकाशित: (2020-11-01)

Bispecific antibody-targeted T-cell therapy for acute myeloid leukemia
द्वारा: Ewa Kubicka, और अन्य
प्रकाशित: (2022-11-01)

Therapeutic Bispecific T-Cell Engager Antibody Targeting the Transferrin Receptor
द्वारा: Mingpeng Fu, और अन्य
प्रकाशित: (2019-06-01)

Characterization of a novel bispecific antibody targeting tissue factor-positive tumors with T cell engagement
द्वारा: Zhidi Pan, और अन्य
प्रकाशित: (2022-04-01)

Development of a bispecific antibody targeting PD-L1 and TIGIT with optimal cytotoxicity
द्वारा: Zhenwei Zhong, और अन्य
प्रकाशित: (2022-10-01)

Targeting tumor vasculature to improve antitumor activity of T cells armed ex vivo with T cell engaging bispecific antibody
द्वारा: Madelyn Espinosa-Cotton, और अन्य
प्रकाशित: (2023-03-01)

Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies
द्वारा: S Jordan Kerns, और अन्य
प्रकाशित: (2021-08-01)

Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes.
द्वारा: Hale, G, और अन्य
प्रकाशित: (1985)

Comparative Analysis of Bispecific Antibody and Streptavidin-Targeted Radioimmunotherapy for B-cell Cancers
द्वारा: Green, Damian J., और अन्य
प्रकाशित: (2020)

Editorial: Bispecific Antibodies for T-Cell Based Immunotherapy
द्वारा: Brian H. Santich, और अन्य
प्रकाशित: (2020-12-01)

Hybrid antibodies for therapy.
द्वारा: Clark, M, और अन्य
प्रकाशित: (1988)

Bispecific, T-Cell-Recruiting Antibodies in B-Cell Malignancies
द्वारा: Margaux Lejeune, और अन्य
प्रकाशित: (2020-05-01)

Bispecific antibodies in indolent B-cell lymphomas
द्वारा: Vivek S. Radhakrishnan, और अन्य
प्रकाशित: (2024-01-01)

Targeting T cells with tetravalent bispecific antibodies for the treatment of graft-versus-host disease
द्वारा: Madelyn Espinosa-Cotton, और अन्य
प्रकाशित: (2025-01-01)

Recent advances of bispecific antibodies in solid tumors
द्वारा: Shengnan Yu, और अन्य
प्रकाशित: (2017-09-01)

Bispecific T cell engager (BiTE®) antibody constructs can mediate bystander tumor cell killing.
द्वारा: Sandra L Ross, और अन्य
प्रकाशित: (2017-01-01)

Modulating tumor infiltrating myeloid cells to enhance bispecific antibody-driven T cell infiltration and anti-tumor response
द्वारा: Jeong A. Park, और अन्य
प्रकाशित: (2021-09-01)

Engineering of dendritic cell bispecific extracellular vesicles for tumor-targeting immunotherapy
द्वारा: Fang Xu, और अन्य
प्रकाशित: (2023-10-01)

Dual Targeting of Tumor Cells with Bispecific Single-Chain Fv-Immunoliposomes
द्वारा: Katharina Mack, और अन्य
प्रकाशित: (2012-07-01)

Co-targeting cancer stem-like cells and bulk cancer cells with a bispecific antibody
द्वारा: Shi Hu
प्रकाशित: (2017-05-01)

Bispecific antibody targets and therapies in multiple myeloma
द्वारा: Matthew Rees, और अन्य
प्रकाशित: (2024-10-01)

Dual-target Bridging ELISA for Bispecific Antibodies
द्वारा: Min Pei, और अन्य
प्रकाशित: (2022-10-01)

T-cell stimulating vaccines empower CD3 bispecific antibody therapy in solid tumors
द्वारा: Jim Middelburg, और अन्य
प्रकाशित: (2024-01-01)

A novel asymmetrical anti-HER2/CD3 bispecific antibody exhibits potent cytotoxicity for HER2-positive tumor cells
द्वारा: Shengnan Yu, और अन्य
प्रकाशित: (2019-08-01)

Blocking of cytotoxic T cell function by monoclonal antibodies against the CD45 antigen (T200/leukocyte-common antigen).
द्वारा: Tighe, H, और अन्य
प्रकाशित: (1987)

Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies
द्वारा: Christian Klein, और अन्य
प्रकाशित: (2021-07-01)

698 PD-L1 targeted CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors
द्वारा: Jing Qi, और अन्य
प्रकाशित: (2021-11-01)

Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy
द्वारा: Amelia C. McCue, और अन्य
प्रकाशित: (2024-12-01)

Overcoming tumor heterogeneity by ex vivo arming of T cells using multiple bispecific antibodies
द्वारा: Nai-Kong V Cheung, और अन्य
प्रकाशित: (2022-01-01)

A Novel T Cell-Engaging Bispecific Antibody for Treating Mesothelin-Positive Solid Tumors
द्वारा: Aerin Yoon, और अन्य
प्रकाशित: (2020-03-01)

The potential of hybrid antibodies secreted by hybrid-hybridomas in tumour therapy.
द्वारा: Clark, M, और अन्य
प्रकाशित: (1988)