Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells.
Previous studies have demonstrated that bispecific hybrid antibodies produced by cell-cell fusion or chemically conjugated heteroaggregates can direct cytotoxic T lymphocytes to kill target cells for which they have no intrinsic specificity, a phenomenon we call effector cell retargeting (ECR). Thes...
Հիմնական հեղինակներ: | Gilliland, L, Clark, MR, Waldmann, H |
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Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
1988
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Նմանատիպ նյութեր
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T-cell killing of target cells induced by hybrid antibodies: comparison of two bispecific monoclonal antibodies.
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: Freedman, J, և այլն
Հրապարակվել է: (2017) -
Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies
: Joshua D Freedman, և այլն
Հրապարակվել է: (2017-06-01) -
Bispecific antibody-activated T cells enhance NK cell-mediated antibody-dependent cellular cytotoxicity
: Zhaoming Wang, և այլն
Հրապարակվել է: (2021-12-01)