Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells.

Previous studies have demonstrated that bispecific hybrid antibodies produced by cell-cell fusion or chemically conjugated heteroaggregates can direct cytotoxic T lymphocytes to kill target cells for which they have no intrinsic specificity, a phenomenon we call effector cell retargeting (ECR). Thes...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Gilliland, L, Clark, MR, Waldmann, H
Format: Journal article
Sprache:English
Veröffentlicht: 1988