Abnormal courtship conditioning in males mutant for the RI regulatory subunit of Drosophila protein kinase A.
The previously described site-selected P-element mutagenesis of a Drosophila gene encoding the regulatory subunit of cAMP-dependent protein kinase generates mutants that have defective behavior in the olfactory learning test. Here we describe the effect of the same mutations in a courtship condition...
| Hoofdauteurs: | , , , |
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| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
1999
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| _version_ | 1826289620011188224 |
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| author | O'Dell, K Jamieson, D Goodwin, S Kaiser, K |
| author_facet | O'Dell, K Jamieson, D Goodwin, S Kaiser, K |
| author_sort | O'Dell, K |
| collection | OXFORD |
| description | The previously described site-selected P-element mutagenesis of a Drosophila gene encoding the regulatory subunit of cAMP-dependent protein kinase generates mutants that have defective behavior in the olfactory learning test. Here we describe the effect of the same mutations in a courtship conditioning assay. Wild-type males can distinguish between virgin females (which they court vigorously), and fertilized females (which they court less vigorously). After exposure to fertilized females, wild-type males modify their behavior by decreasing courtship to subsequent target virgins, an effect that may last for many hours. Like wild-type males, PKA-RI mutant males are also able to distinguish between virgin and fertilized females. PKA-RI males also modify their behavior towards virgin females after prior exposure to a fertilized female, but such an effect is short-lived, suggesting a defect in memory rather than learning. We also show that under these conditions the behavior of PKA-RI males is similar to that of amnesiac, dunce and rutabaga males. |
| first_indexed | 2024-03-07T02:31:39Z |
| format | Journal article |
| id | oxford-uuid:a76f5ed2-fd9c-40f9-8c41-f1247f9c7294 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:31:39Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:a76f5ed2-fd9c-40f9-8c41-f1247f9c72942022-03-27T02:54:39ZAbnormal courtship conditioning in males mutant for the RI regulatory subunit of Drosophila protein kinase A.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a76f5ed2-fd9c-40f9-8c41-f1247f9c7294EnglishSymplectic Elements at Oxford1999O'Dell, KJamieson, DGoodwin, SKaiser, KThe previously described site-selected P-element mutagenesis of a Drosophila gene encoding the regulatory subunit of cAMP-dependent protein kinase generates mutants that have defective behavior in the olfactory learning test. Here we describe the effect of the same mutations in a courtship conditioning assay. Wild-type males can distinguish between virgin females (which they court vigorously), and fertilized females (which they court less vigorously). After exposure to fertilized females, wild-type males modify their behavior by decreasing courtship to subsequent target virgins, an effect that may last for many hours. Like wild-type males, PKA-RI mutant males are also able to distinguish between virgin and fertilized females. PKA-RI males also modify their behavior towards virgin females after prior exposure to a fertilized female, but such an effect is short-lived, suggesting a defect in memory rather than learning. We also show that under these conditions the behavior of PKA-RI males is similar to that of amnesiac, dunce and rutabaga males. |
| spellingShingle | O'Dell, K Jamieson, D Goodwin, S Kaiser, K Abnormal courtship conditioning in males mutant for the RI regulatory subunit of Drosophila protein kinase A. |
| title | Abnormal courtship conditioning in males mutant for the RI regulatory subunit of Drosophila protein kinase A. |
| title_full | Abnormal courtship conditioning in males mutant for the RI regulatory subunit of Drosophila protein kinase A. |
| title_fullStr | Abnormal courtship conditioning in males mutant for the RI regulatory subunit of Drosophila protein kinase A. |
| title_full_unstemmed | Abnormal courtship conditioning in males mutant for the RI regulatory subunit of Drosophila protein kinase A. |
| title_short | Abnormal courtship conditioning in males mutant for the RI regulatory subunit of Drosophila protein kinase A. |
| title_sort | abnormal courtship conditioning in males mutant for the ri regulatory subunit of drosophila protein kinase a |
| work_keys_str_mv | AT odellk abnormalcourtshipconditioninginmalesmutantfortheriregulatorysubunitofdrosophilaproteinkinasea AT jamiesond abnormalcourtshipconditioninginmalesmutantfortheriregulatorysubunitofdrosophilaproteinkinasea AT goodwins abnormalcourtshipconditioninginmalesmutantfortheriregulatorysubunitofdrosophilaproteinkinasea AT kaiserk abnormalcourtshipconditioninginmalesmutantfortheriregulatorysubunitofdrosophilaproteinkinasea |