Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.

Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.

Clear-cut inherited Mendelian traits, such as familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer, account for <4% of colorectal cancers. Another 20% of all colorectal cancers are thought to occur in individuals with a significant inherited multifactorial susceptibilit...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Fearnhead, N, Wilding, J, Winney, B, Tonks, S, Bartlett, S, Bicknell, D, Tomlinson, I, Mortensen, N, Bodmer, W
التنسيق:	Journal article
اللغة:	English
منشور في:	2004

مواد مشابهة

Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model.
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The HLA system and the analysis of multifactorial genetic disease.
حسب: Tomlinson, I, وآخرون
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Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer.
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Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas.
حسب: Beck, N, وآخرون
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Mechanisms of loss of HLA class I expression on colorectal tumor cells.
حسب: Browning, M, وآخرون
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Genetic susceptibility to multifactorial diseases.
حسب: Hill, A
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