Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.

Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.

Clear-cut inherited Mendelian traits, such as familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer, account for <4% of colorectal cancers. Another 20% of all colorectal cancers are thought to occur in individuals with a significant inherited multifactorial susceptibilit...

書目詳細資料
Main Authors:	Fearnhead, N, Wilding, J, Winney, B, Tonks, S, Bartlett, S, Bicknell, D, Tomlinson, I, Mortensen, N, Bodmer, W
格式:	Journal article
語言:	English
出版:	2004

相似書籍

Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model.
由: Fearnhead, N, et al.
出版: (2005)

Common and rare variants in multifactorial susceptibility to common diseases.
由: Bodmer, W, et al.
出版: (2008)

Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients.
由: Bonilla, C, et al.
出版: (2011)

Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients
由: Bonilla, C, et al.
出版: (2015)

Genetics of colorectal cancer: hereditary aspects and overview of colorectal tumorigenesis.
由: Fearnhead, N, et al.
出版: (2002)

Genetic Variants Associated with Colorectal Adenoma Susceptibility.
由: Anna Abulí, et al.
出版: (2016-01-01)

Targeted killing of colorectal cell lines and murine adenomas using a monoclonal antibody against membrane bound carcinoembryonic antigen
由: Conaghan, P, et al.
出版: (2006)

Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22.
由: Tomlinson, I, et al.
出版: (1999)

The HLA system and the analysis of multifactorial genetic disease.
由: Tomlinson, I, et al.
出版: (1995)

Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer.
由: Lefevre, J, et al.
出版: (2012)

Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer
由: Lefevre, J, et al.
出版: (2012)

Mutations in the AXIN1 gene in advanced prostate cancer.
由: Yardy, G, et al.
出版: (2009)

Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas.
由: Beck, N, et al.
出版: (1997)

Educational Case: Genetic Mutations and Multifactorial Inheritance
由: Eric S. Suarez MD, et al.
出版: (2017-08-01)

Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission.
由: Preston, S, et al.
出版: (2003)

European camparison populations needed, can you help?
由: Tonks, S, et al.
出版: (2007)

A SNP approach to HLA typing analysis
由: Evseeva, I, et al.
出版: (2005)

Multiple abnormalities in a foetus: a possibility of multifactorial inheritance disorder
由: D N Sinha
出版: (2016-01-01)

Targeted killing of colorectal cancer cell lines by a humanised IgG1 monoclonal antibody that binds to membrane-bound carcinoembryonic antigen.
由: Conaghan, P, et al.
出版: (2008)

Germline mutations in the mismatch repair genes hMLH1 and hMSH2 may predispose to the formation of multiple adenomatous polyps
由: Fearnhead, N, et al.
出版: (2002)

Ceramide signalling in inherited and multifactorial brain metabolic diseases
由: Devesh C. Pant, et al.
出版: (2020-09-01)

The diversity of mitochondrial sequences in Eurasia
由: Tonks, S, et al.
出版: (2005)

Mechanisms of loss of HLA class I expression on colorectal tumor cells.
由: Browning, M, et al.
出版: (1996)

Genetic susceptibility to multifactorial diseases.
由: Hill, A
出版: (1997)

APC mutations are sufficient for the growth of early colorectal adenomas.
由: Lamlum, H, et al.
出版: (2000)

Top down or bottom up morphogenesis of colorectal adenomas: Competing management structures in the origins of colorectal neoplasia
由: Preston, S, et al.
出版: (2003)

Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q.
由: Lamlum, H, et al.
出版: (2000)

A common mtDNA variant may be a susceptibility factor in 3 multifactorial diseases.
由: Poulton, J, et al.
出版: (2001)

Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.
由: Carvajal-Carmona, L, et al.
出版: (2013)

Criteria for choosing non-patient control groups in genetically based case-control studies in the United Kingdom. People of the British Isles: the pilot project
由: Evseeva, I, et al.
出版: (2007)

Direct and immune mediated antibody targeting of ERBB receptors in a colorectal cancer cell-line panel.
由: Ashraf, S, et al.
出版: (2012)

Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines.
由: Wong, N, et al.
出版: (2004)

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma.
由: Lipton, L, et al.
出版: (2003)

Germline HNPCC gene variants have little influence on the risk for sporadic colorectal cancer.
由: Tomlinson, I, et al.
出版: (1997)

Etiology and familial inheritance of pleomorphic adenomas
由: Krysten Clark
出版: (2017-06-01)

The influence of modifier genes on the disease phenotype in South African families with hereditary nonpolyposis colorectal cancer (HNPCC).
由: Felix, R, et al.
出版: (2003)

Top-down or bottom-up morphogenesis of colorectal adenomas: Competing management structures in the origins of colonic neoplasia
由: Preston, S, et al.
出版: (2003)

Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants
由: Crouch, DJM, et al.
出版: (2020)

Rare genetic variants and the risk of cancer.
由: Bodmer, W, et al.
出版: (2010)

CDX2 mutations do not account for juvenile polyposis or Peutz-Jeghers syndrome and occur infrequently in sporadic colorectal cancers.
由: Woodford-Richens, K, et al.
出版: (2001)