Functional epistasis on a common MHC haplotype associated with multiple sclerosis.

Functional epistasis on a common MHC haplotype associated with multiple sclerosis.

Genes in the major histocompatibility complex (MHC) encode proteins important in activating antigen-specific immune responses. Alleles at adjacent MHC loci are often in strong linkage disequilibrium; however, little is known about the mechanisms responsible for this linkage disequilibrium. Here we r...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Gregersen, J, Kranc, K, Ke, X, Svendsen, P, Madsen, L, Thomsen, A, Cardon, L, Bell, J, Fugger, L
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2006

Παρόμοια τεκμήρια

Multiple sclerosis: MHC associations and therapeutic implications.
ανά: Holmes, S, κ.ά.
Έκδοση: (2005)

Multiple Epistasis Interactions Within MHC Are Associated With Ulcerative Colitis
ανά: Jie Zhang, κ.ά.
Έκδοση: (2019-04-01)

Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance.
ανά: Dyment, D, κ.ά.
Έκδοση: (2005)

Dissection of the multiple sclerosis associated DR2 haplotype.
ανά: Etzensperger, R, κ.ά.
Έκδοση: (2008)

Epistasis: multiple sclerosis and the major histocompatibility complex.
ανά: Ramagopalan, S, κ.ά.
Έκδοση: (2009)

Genetic susceptibility to multiple sclerosis: interactions between conserved extended haplotypes of the MHC and other susceptibility regions
ανά: D. S. Goodin, κ.ά.
Έκδοση: (2021-07-01)

PCR-RFLP Genotyping of Murine MHC Haplotypes
ανά: Stanford L. Peng, κ.ά.
Έκδοση: (1996-09-01)

Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium
ανά: Chao, M, κ.ά.
Έκδοση: (2007)

Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium.
ανά: Chao, M, κ.ά.
Έκδοση: (2007)

From genes to function: the next challenge to understanding multiple sclerosis
ανά: Fugger, L, κ.ά.
Έκδοση: (2009)

From genes to function: the next challenge to understanding multiple sclerosis.
ανά: Fugger, L, κ.ά.
Έκδοση: (2009)

A clinical conundrum: the detrimental effect of TNF antagonists in multiple sclerosis.
ανά: Dendrou, C, κ.ά.
Έκδοση: (2013)

Efficiency and consistency of haplotype tagging of dense SNP maps in multiple samples.
ανά: Ke, X, κ.ά.
Έκδοση: (2004)

The value of animal models for drug development in multiple sclerosis
ανά: Friese, M, κ.ά.
Έκδοση: (2006)

The value of animal models for drug development in multiple sclerosis.
ανά: Friese, M, κ.ά.
Έκδοση: (2006)

Epistasis in complex human traits
ανά: Bell, J, κ.ά.
Έκδοση: (2006)

MHC Class II haplotypes of Colombian Amerindian tribes
ανά: Juan J. Yunis, κ.ά.
Έκδοση: (2013-01-01)

Comparison of the Accuracy of Epistasis and Haplotype Models for Genomic Prediction of Seven Human Phenotypes
ανά: Zuoxiang Liang, κ.ά.
Έκδοση: (2023-10-01)

The immunology of multiple sclerosis
ανά: Attfield, KE, κ.ά.
Έκδοση: (2022)

MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction.
ανά: Swanberg, M, κ.ά.
Έκδοση: (2005)

Immunomodulation in multiple sclerosis: promises and pitfalls
ανά: Dendrou, C, κ.ά.
Έκδοση: (2017)

Multifactorial methods integrating haplotype and epistasis effects for genomic estimation and prediction of quantitative traits
ανά: Yang Da, κ.ά.
Έκδοση: (2022-10-01)

Epigenetic mechanisms in multiple sclerosis and the major histocompatibility complex (MHC).
ανά: Burrell, A, κ.ά.
Έκδοση: (2011)

Discovery of novel MHC-B haplotypes in Chantecler chickens
ανά: Corie Darrington, κ.ά.
Έκδοση: (2023-09-01)

The MHC and multiple sclerosis susceptibility - several levels of complexity
ανά: Ebers, G, κ.ά.
Έκδοση: (2004)

T cells and microglia as drivers of multiple sclerosis pathology.
ανά: Friese, M, κ.ά.
Έκδοση: (2007)

T cells and microglia as drivers of multiple sclerosis pathology
ανά: Friese, M, κ.ά.
Έκδοση: (2007)

Pathogenic CD8(+) T cells in multiple sclerosis.
ανά: Friese, M, κ.ά.
Έκδοση: (2009)

A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.
ανά: de Bakker, P, κ.ά.
Έκδοση: (2006)

Interleukin-17 expression in multiple sclerosis
ανά: Tzartos, J, κ.ά.
Έκδοση: (2006)

Unique Allelic eQTL Clusters in Human MHC Haplotypes
ανά: Tze Hau Lam, κ.ά.
Έκδοση: (2017-08-01)

MHC class II proteins and disease: a structural perspective.
ανά: Jones, E, κ.ά.
Έκδοση: (2006)

MHC class II proteins and disease: a structural perspective
ανά: Jones, E, κ.ά.
Έκδοση: (2006)

Considerations in the search for epistasis
ανά: Balvert, M, κ.ά.
Έκδοση: (2024)

MHC II molecules in inflammatory diseases: interplay of qualities and quantities.
ανά: Friese, M, κ.ά.
Έκδοση: (2005)

Misfiring in multiple sclerosis: cerebellar channelopathy, a potential novel target?
ανά: Craner, M, κ.ά.
Έκδοση: (2012)

A functional and structural basis for TCR cross-reactivity in multiple sclerosis.
ανά: Lang, H, κ.ά.
Έκδοση: (2002)

MHConstructor: a high-throughput, haplotype-informed solution to the MHC assembly challenge
ανά: Kristen J. Wade, κ.ά.
Έκδοση: (2024-10-01)

Mixed-haplotype MHC class II molecules select functional CD4+ T cells.
ανά: Silk, J, κ.ά.
Έκδοση: (2005)

MHC CLASS II HUMANIZED MICE DEFINE A T CELL EPITOPE IN GOODPASTURE'S DISEASE
ανά: Ooi, J, κ.ά.
Έκδοση: (2008)