The two activation domains of the Brn-3a transcription factor have distinct functional properties

The two activation domains of the Brn-3a transcription factor have distinct functional properties

The Brn-3a transcription factor has two distinct activation domains located, respectively, at the N-terminus and the C-terminus (coincident with the DNA binding POU domain) which differ in their effects on different target promoters. To analyze whether these regions could function when linked to a h...

Descripció completa

Dades bibliogràfiques
Autors principals:	Begbie, J, Latchman, D
Format:	Journal article
Idioma:	English
Publicat:	1997

Ítems similars

NT-3 regulates expression of Brn3a but not Brn3b in developing mouse trigeminal sensory neurons.
per: Wyatt, S, et al.
Publicat: (1998)

Specific up-regulation of the POU domain transcription factor Oct-2 following axotomy.
per: Begbie, J, et al.
Publicat: (1996)

The role of the transcription factor BRN2 in melanoma
per: Herbert, K
Publicat: (2018)

The Brn-2 transcription factor links activated BRAF to melanoma proliferation.
per: Goodall, J, et al.
Publicat: (2004)

Targeting Neuronal Transcription Factor BRN2 in Neuroendocrine Tumors
per: Ravi Munuganti, et al.
Publicat: (2019-08-01)

Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells.
per: Goodall, J, et al.
Publicat: (2008)

Transcription factors Brn-3α and TRIM16 in cancers, association with hormone reception
per: Liudmila V. Spirina, et al.
Publicat: (2019-08-01)

The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression.
per: Eisen, T, et al.
Publicat: (1995)

Genetic interactions between Brn3 transcription factors in retinal ganglion cell type specification.
per: Melody Shi, et al.
Publicat: (2013-01-01)

Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion
per: Soraia Barão, et al.
Publicat: (2024-09-01)

TRANSCRIPTION FACTOR BRN-3α AND PROSTATE CANCER, RELATION WITH HORMONE RECEPTORS AND AKT/M-TOR SIGNALING PATHWAY ACTIVATION
per: L. V. Spirina, et al.
Publicat: (2018-03-01)

The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival
per: Tobias Hohenauer, et al.
Publicat: (2013-05-01)

The HPV Cellular Transactivator Brn-3a Can Be Used to Predict Cervical Adenocarcinoma and Squamous Carcinoma Precancer Lesions in the Developed and Developing Worlds
per: Daniel Ndisang, et al.
Publicat: (2009-01-01)

Brn2 is a transcription factor regulating keratinocyte differentiation with a possible role in the pathogenesis of lichen planus.
per: Ge Shi, et al.
Publicat: (2010-01-01)

Runx3, Brn3a and Isl1 interplay orchestrates the transcriptional program in the early stages of proprioceptive neuron development.
per: Kira Orlovsky, et al.
Publicat: (2024-12-01)

Regulation of MITF and Brn2 in melanoma
per: Agkatsev, S
Publicat: (2014)

The leucine zipper domains of the transcription factors GCN4 and c-Jun have ribonuclease activity.
per: Yaroslav Nikolaev, et al.
Publicat: (2010-01-01)

Importance of BRN2 phosphorylation for melanocyte migration
per: Berlin, I, et al.
Publicat: (2011)

Distinct properties of hexameric but functionally conserved Mycobacterium tuberculosis transcription-repair coupling factor.
per: Swayam Prabha, et al.
Publicat: (2011-01-01)

From shared lineage to distinct functions: the development of the inner ear and epibranchial placodes.
per: Ladher, R, et al.
Publicat: (2010)

Hypoxia-Inducible Factor 3 Is an Oxygen-Dependent Transcription Activator and Regulates a Distinct Transcriptional Response to Hypoxia
per: Peng Zhang, et al.
Publicat: (2014-03-01)

DNA specificity determinants associate with distinct transcription factor functions.
per: Peter C Hollenhorst, et al.
Publicat: (2009-12-01)

Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancer
per: Ahmed Nuzhat, et al.
Publicat: (2010-07-01)

A phosphatidylinositol 3-kinase-Pax3 axis regulates Brn-2 expression in melanoma.
per: Bonvin, E, et al.
Publicat: (2012)

Crystal structure of 5-bromopyrimidine, C4H3BrN2
per: Staples Richard J., et al.
Publicat: (2007-09-01)

Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways
per: Vaishaali Yogendran, et al.
Publicat: (2023-11-01)

BRN2 is a non-canonical melanoma tumor-suppressor
per: Hamm, M, et al.
Publicat: (2021)

Transcriptional Modulation of Heat-Shock Protein Gene Expression
per: Anastasis Stephanou, et al.
Publicat: (2011-01-01)

BRN2 phosphorylation regulates melanoblast migration and proliferation through PAX3 and MITF-M
per: Berlin, I, et al.
Publicat: (2011)

A LytM-Domain Factor, ActS, Functions in Two Distinctive Peptidoglycan Hydrolytic Pathways in E. coli
per: Pavan Kumar Chodisetti, et al.
Publicat: (2022-06-01)

The activation domain of a basic helix-loop-helix protein is masked by repressor interaction with domains distinct from that required for transcription regulation.
per: Jayaraman, P, et al.
Publicat: (1994)

Fungi have three tetraspanin families with distinct functions
per: Martin Francis, et al.
Publicat: (2008-02-01)

Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima
per: Ekaterina Morgunova, et al.
Publicat: (2018-04-01)

Phosphorylation of BRN2 modulates its interaction with the Pax3 promoter to control melanocyte migration and proliferation.
per: Berlin, I, et al.
Publicat: (2012)

Brn3b regulates the formation of fear-related midbrain circuits and defensive responses to visual threat.
per: Hyoseo Lee, et al.
Publicat: (2023-11-01)

MMS21/HPY2 and SIZ1, two Arabidopsis SUMO E3 ligases, have distinct functions in development.
per: Takashi Ishida, et al.
Publicat: (2012-01-01)

The two PPX-GppA homologues from Mycobacterium tuberculosis have distinct biochemical activities.
per: Mei Y Choi, et al.
Publicat: (2012-01-01)

SH3 Domains Differentially Stimulate Distinct Dynamin I Assembly Modes and G Domain Activity.
per: Sai Krishnan, et al.
Publicat: (2015-01-01)

The crystal structure of 4-(3-bromophenyl)pyrimidin-2-amine, C 10 H 8 BrN 3
per: Khan, A, et al.
Publicat: (2021)

The crystal structure of 4-(3-bromophenyl)pyrimidin-2-amine, C10H8BrN3
per: Khan Arshad, et al.
Publicat: (2021-09-01)