Mammalian base excision repair: the forgotten archangel.
Base excision repair (BER) is a frontline repair system that is responsible for maintaining genome integrity and thus preventing premature aging, cancer and many other human diseases by repairing thousands of DNA lesions and strand breaks continuously caused by endogenous and exogenous mutagens. Thi...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2013
|
| _version_ | 1826289676980322304 |
|---|---|
| author | Dianov, G Hübscher, U |
| author_facet | Dianov, G Hübscher, U |
| author_sort | Dianov, G |
| collection | OXFORD |
| description | Base excision repair (BER) is a frontline repair system that is responsible for maintaining genome integrity and thus preventing premature aging, cancer and many other human diseases by repairing thousands of DNA lesions and strand breaks continuously caused by endogenous and exogenous mutagens. This fundamental and essential function of BER not only necessitates tight control of the continuous availability of basic components for fast and accurate repair, but also requires temporal and spatial coordination of BER and cell cycle progression to prevent replication of damaged DNA. The major goal of this review is to critically examine controversial and newly emerging questions about mammalian BER pathways, mechanisms regulating BER capacity, BER responses to DNA damage and their links to checkpoint control of DNA replication. |
| first_indexed | 2024-03-07T02:32:32Z |
| format | Journal article |
| id | oxford-uuid:a7b9aa9d-e409-4da9-87fe-671cbb31b182 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:32:32Z |
| publishDate | 2013 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:a7b9aa9d-e409-4da9-87fe-671cbb31b1822022-03-27T02:56:29ZMammalian base excision repair: the forgotten archangel.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a7b9aa9d-e409-4da9-87fe-671cbb31b182EnglishSymplectic Elements at OxfordOxford University Press2013Dianov, GHübscher, UBase excision repair (BER) is a frontline repair system that is responsible for maintaining genome integrity and thus preventing premature aging, cancer and many other human diseases by repairing thousands of DNA lesions and strand breaks continuously caused by endogenous and exogenous mutagens. This fundamental and essential function of BER not only necessitates tight control of the continuous availability of basic components for fast and accurate repair, but also requires temporal and spatial coordination of BER and cell cycle progression to prevent replication of damaged DNA. The major goal of this review is to critically examine controversial and newly emerging questions about mammalian BER pathways, mechanisms regulating BER capacity, BER responses to DNA damage and their links to checkpoint control of DNA replication. |
| spellingShingle | Dianov, G Hübscher, U Mammalian base excision repair: the forgotten archangel. |
| title | Mammalian base excision repair: the forgotten archangel. |
| title_full | Mammalian base excision repair: the forgotten archangel. |
| title_fullStr | Mammalian base excision repair: the forgotten archangel. |
| title_full_unstemmed | Mammalian base excision repair: the forgotten archangel. |
| title_short | Mammalian base excision repair: the forgotten archangel. |
| title_sort | mammalian base excision repair the forgotten archangel |
| work_keys_str_mv | AT dianovg mammalianbaseexcisionrepairtheforgottenarchangel AT hubscheru mammalianbaseexcisionrepairtheforgottenarchangel |