CBP/p300 bromodomains regulate amyloid-like protein aggregation upon aberrant lysine acetylation

CBP/p300 bromodomains regulate amyloid-like protein aggregation upon aberrant lysine acetylation

Lysine acetylation is becoming increasingly recognized as a general biological principle in cellular homeostasis, and is subject to abnormal control in different human pathologies. Here, we describe a global effect on amyloid-like protein aggregation in human cells that results from aberrant lysine...

Полное описание

Библиографические подробности
Главные авторы:	Olzscha, H, Fedorov, O, Kessler, B, Knapp, S, La Thangue, N
Формат:	Journal article
Язык:	English
Опубликовано:	Cell Press 2016

Схожие документы

Bromodomains control amyloid-like aggregation of aberrantly acetylated proteins
по: Olzscha, H, и др.
Опубликовано: (2018)

Development of selective CBP/P300 benzoxazepine bromodomain inhibitors
по: Popp, T, и др.
Опубликовано: (2016)

Targeting bromodomains: epigenetic readers of lysine acetylation.
по: Filippakopoulos, P, и др.
Опубликовано: (2014)

Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains
по: Hay, D, и др.
Опубликовано: (2014)

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.
по: Hammitzsch, A, и др.
Опубликовано: (2015)

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.
по: Hewings, D, и др.
Опубликовано: (2011)

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
по: Picaud, S, и др.
Опубликовано: (2015)

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands
по: Hewings, D, и др.
Опубликовано: (2011)

Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites.
по: Vidler, L, и др.
Опубликовано: (2012)

Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP.
по: Crump, N, и др.
Опубликовано: (2011)

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming
по: Ebrahimi, A, и др.
Опубликовано: (2019)

Dissecting the role of CBP/P300-mediated acetylation in enhancer function
по: Jackson, N
Опубликовано: (2023)

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions.
по: Hewings, D, и др.
Опубликовано: (2012)

Cracking the histone code: Developing inhibitors of bromodomain-acetyl-lysine interactions
по: Conway, S
Опубликовано: (2013)

The therapeutic potential of acetyl-lysine and methyl-lysine effector domains
по: Brennan, P, и др.
Опубликовано: (2012)

The therapeutic potential of acetyl-lysine and methyl-lysine effector domains
по: Brennan, P, и др.
Опубликовано: (2012)

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
по: Cohen, H, и др.
Опубликовано: (2004)

Quantitative Profiling of Lysine Acetylation Reveals Dynamic Crosstalk between Receptor Tyrosine Kinases and Lysine Acetylation
по: Bryson, Bryan D., и др.
Опубликовано: (2015)

Isoxazole-derived amino acids are bromodomain-binding acetyl-lysine mimics: incorporation into histone H4 peptides and histone H3
по: Conway, S, и др.
Опубликовано: (2016)

CBP/p300 as a co-factor for the Microphthalmia transcription factor.
по: Sato, S, и др.
Опубликовано: (1997)

Acetylation at lysine 183 of progesterone receptor by p300 accelerates DNA binding kinetics and transactivation of direct target genes
по: Sze, Siu Kwan, и др.
Опубликовано: (2015)

Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition.
по: Dancy, B, и др.
Опубликовано: (2012)

Discovery of pyrrolo[3,2-d]pyrimidin-4-one derivatives as a new class of potent and cell-active inhibitors of P300/CBP-associated factor bromodomain
по: Huang, L, и др.
Опубликовано: (2019)

Lysine methylation and the regulation of p53.
по: Carr, S, и др.
Опубликовано: (2012)

Small molecules as tools to study the chemical epigenetics of lysine acetylation
по: Schiedel, M, и др.
Опубликовано: (2018)

Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis
по: Finkemeier, I, и др.
Опубликовано: (2011)

Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis.
по: Finkemeier, I, и др.
Опубликовано: (2011)

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein.
по: Carr, S, и др.
Опубликовано: (2011)

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein.
по: Carr, S, и др.
Опубликовано: (2011)

Selective inhibition of BET bromodomains.
по: Filippakopoulos, P, и др.
Опубликовано: (2010)

Selective inhibition of BET bromodomains.
по: Filippakopoulos, P, и др.
Опубликовано: (2010)

The bromodomain interaction module.
по: Filippakopoulos, P, и др.
Опубликовано: (2012)

The bromodomain interaction module
по: Filippakopoulos, P, и др.
Опубликовано: (2012)

Bromodomains as therapeutic targets.
по: Muller, S, и др.
Опубликовано: (2011)

Biosensing strategies for amyloid‐like protein aggregates
по: Zhou, Y, и др.
Опубликовано: (2023)

Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein
по: Carr, S, и др.
Опубликовано: (2017)

Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
по: van Noort, V, и др.
Опубликовано: (2012)

Distinct and Predictive Histone Lysine Acetylation Patterns at Promoters, Enhancers, and Gene Bodies
по: Rajagopal, Nisha, и др.
Опубликовано: (2015)

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.
по: Bowers, E, и др.
Опубликовано: (2010)

Developing chemical probes for the BET bromodomains
по: Hewings, D, и др.
Опубликовано: (2012)