Airway function and markers of airway inflammation in patients with treated hypothyroidism.
BACKGROUND: There is increasing evidence of an association between organ specific autoimmune diseases, particularly autoimmune thyroid disease and respiratory morbidity. A study was undertaken to determine whether patients with autoimmune thyroid disease have objective evidence of airway inflammatio...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| _version_ | 1797087231888850944 |
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| author | Birring, S Patel, R Parker, D McKenna, S Hargadon, B Monteiro, W Falconer Smith, J Pavord, I |
| author_facet | Birring, S Patel, R Parker, D McKenna, S Hargadon, B Monteiro, W Falconer Smith, J Pavord, I |
| author_sort | Birring, S |
| collection | OXFORD |
| description | BACKGROUND: There is increasing evidence of an association between organ specific autoimmune diseases, particularly autoimmune thyroid disease and respiratory morbidity. A study was undertaken to determine whether patients with autoimmune thyroid disease have objective evidence of airway inflammation and dysfunction. METHODS: Twenty six non-smoking women with treated hypothyroidism and 19 non-smoking controls completed a symptom questionnaire and underwent full lung function tests, capsaicin cough reflex sensitivity measurement, methacholine challenge test, and sputum induction over two visits. RESULTS: Symptoms of cough (p = 0.01), dyspnoea (p = 0.01), sputum production (p = 0.004), and wheeze (p = 0.04) were reported more commonly in patients than controls. Patients with hypothyroidism had heightened cough reflex sensitivity compared with controls (geometric mean concentration of capsaicin causing five coughs: 40 v 108 mmol/l; mean difference 1.4 doubling doses; 95% confidence interval of difference 0.4 to 2.5; p = 0.008) and a significantly higher proportion of patients had airway hyperresponsiveness (methacholine provocative concentration (PC(20)) <8 mg/ml: 38% v 0%; p = 0.016). Patients with hypothyroidism also had a significantly higher induced sputum total neutrophil cell count (p = 0.01), total lymphocyte count (p = 0.02), and sputum supernatant interleukin-8 concentrations (p = 0.048). CONCLUSION: Patients with treated hypothyroidism report more respiratory symptoms and have objective evidence of airway dysfunction and inflammation. |
| first_indexed | 2024-03-07T02:32:52Z |
| format | Journal article |
| id | oxford-uuid:a7d6e670-1df8-4b40-aac3-9fa9fa79a939 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:32:52Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:a7d6e670-1df8-4b40-aac3-9fa9fa79a9392022-03-27T02:57:11ZAirway function and markers of airway inflammation in patients with treated hypothyroidism.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a7d6e670-1df8-4b40-aac3-9fa9fa79a939EnglishSymplectic Elements at Oxford2005Birring, SPatel, RParker, DMcKenna, SHargadon, BMonteiro, WFalconer Smith, JPavord, IBACKGROUND: There is increasing evidence of an association between organ specific autoimmune diseases, particularly autoimmune thyroid disease and respiratory morbidity. A study was undertaken to determine whether patients with autoimmune thyroid disease have objective evidence of airway inflammation and dysfunction. METHODS: Twenty six non-smoking women with treated hypothyroidism and 19 non-smoking controls completed a symptom questionnaire and underwent full lung function tests, capsaicin cough reflex sensitivity measurement, methacholine challenge test, and sputum induction over two visits. RESULTS: Symptoms of cough (p = 0.01), dyspnoea (p = 0.01), sputum production (p = 0.004), and wheeze (p = 0.04) were reported more commonly in patients than controls. Patients with hypothyroidism had heightened cough reflex sensitivity compared with controls (geometric mean concentration of capsaicin causing five coughs: 40 v 108 mmol/l; mean difference 1.4 doubling doses; 95% confidence interval of difference 0.4 to 2.5; p = 0.008) and a significantly higher proportion of patients had airway hyperresponsiveness (methacholine provocative concentration (PC(20)) <8 mg/ml: 38% v 0%; p = 0.016). Patients with hypothyroidism also had a significantly higher induced sputum total neutrophil cell count (p = 0.01), total lymphocyte count (p = 0.02), and sputum supernatant interleukin-8 concentrations (p = 0.048). CONCLUSION: Patients with treated hypothyroidism report more respiratory symptoms and have objective evidence of airway dysfunction and inflammation. |
| spellingShingle | Birring, S Patel, R Parker, D McKenna, S Hargadon, B Monteiro, W Falconer Smith, J Pavord, I Airway function and markers of airway inflammation in patients with treated hypothyroidism. |
| title | Airway function and markers of airway inflammation in patients with treated hypothyroidism. |
| title_full | Airway function and markers of airway inflammation in patients with treated hypothyroidism. |
| title_fullStr | Airway function and markers of airway inflammation in patients with treated hypothyroidism. |
| title_full_unstemmed | Airway function and markers of airway inflammation in patients with treated hypothyroidism. |
| title_short | Airway function and markers of airway inflammation in patients with treated hypothyroidism. |
| title_sort | airway function and markers of airway inflammation in patients with treated hypothyroidism |
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