NIPT for adult‐onset conditions: Australian NIPT users' views
Noninvasive prenatal testing (NIPT) has become widely available in recent years. While initially used to screen for trisomies 21, 18, and 13, the test has expanded to include a range of other conditions and will likely expand further. This paper addresses the ethical issues that arise from one parti...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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Wiley
2024
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| _version_ | 1811140161717665792 |
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| author | Marks, IR Devolder, K Bowman‐Smart, H Johnston, M Mills, C |
| author_facet | Marks, IR Devolder, K Bowman‐Smart, H Johnston, M Mills, C |
| author_sort | Marks, IR |
| collection | OXFORD |
| description | Noninvasive prenatal testing (NIPT) has become widely available in recent years. While initially used to screen for trisomies 21, 18, and 13, the test has expanded to include a range of other conditions and will likely expand further. This paper addresses the ethical issues that arise from one particularly controversial potential use of NIPT: screening for adult‐onset conditions (AOCs). We report data from our quantitative survey of Australian NIPT users' views on the ethical issues raised by NIPT for AOCs. The survey ascertained support for NIPT for several traits and conditions including AOCs. Participants were then asked about their level of concern around implications of screening for AOCs for the future child and parent(s). Descriptive and comparative data analyses were conducted. In total, 109 respondents were included in data analysis. The majority of respondents expressed support for NIPT screening for preventable (70.9%) and nonpreventable AOCs (80.8%). Most respondents indicated concern around potential harmful impacts associated with NIPT for AOCs, including the psychological impact on the future child and on the parent(s). Despite this, the majority of participants thought that continuation of a pregnancy known to be predisposed to an AOC is ethically acceptable. The implications of these data are critically discussed and used to inform the normative claim that prospective parents should be given access to NIPT for AOCs. The study contributes to a body of research debating the ethical acceptability and regulation of various applications of NIPT as screening panels expand. |
| first_indexed | 2024-09-25T04:17:35Z |
| format | Journal article |
| id | oxford-uuid:a7e9163e-993c-4711-accd-b256d7c0fc29 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:17:35Z |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:a7e9163e-993c-4711-accd-b256d7c0fc292024-07-20T16:22:31ZNIPT for adult‐onset conditions: Australian NIPT users' viewsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a7e9163e-993c-4711-accd-b256d7c0fc29EnglishJisc Publications RouterWiley2024Marks, IRDevolder, KBowman‐Smart, HJohnston, MMills, CNoninvasive prenatal testing (NIPT) has become widely available in recent years. While initially used to screen for trisomies 21, 18, and 13, the test has expanded to include a range of other conditions and will likely expand further. This paper addresses the ethical issues that arise from one particularly controversial potential use of NIPT: screening for adult‐onset conditions (AOCs). We report data from our quantitative survey of Australian NIPT users' views on the ethical issues raised by NIPT for AOCs. The survey ascertained support for NIPT for several traits and conditions including AOCs. Participants were then asked about their level of concern around implications of screening for AOCs for the future child and parent(s). Descriptive and comparative data analyses were conducted. In total, 109 respondents were included in data analysis. The majority of respondents expressed support for NIPT screening for preventable (70.9%) and nonpreventable AOCs (80.8%). Most respondents indicated concern around potential harmful impacts associated with NIPT for AOCs, including the psychological impact on the future child and on the parent(s). Despite this, the majority of participants thought that continuation of a pregnancy known to be predisposed to an AOC is ethically acceptable. The implications of these data are critically discussed and used to inform the normative claim that prospective parents should be given access to NIPT for AOCs. The study contributes to a body of research debating the ethical acceptability and regulation of various applications of NIPT as screening panels expand. |
| spellingShingle | Marks, IR Devolder, K Bowman‐Smart, H Johnston, M Mills, C NIPT for adult‐onset conditions: Australian NIPT users' views |
| title | NIPT for adult‐onset conditions: Australian NIPT users' views |
| title_full | NIPT for adult‐onset conditions: Australian NIPT users' views |
| title_fullStr | NIPT for adult‐onset conditions: Australian NIPT users' views |
| title_full_unstemmed | NIPT for adult‐onset conditions: Australian NIPT users' views |
| title_short | NIPT for adult‐onset conditions: Australian NIPT users' views |
| title_sort | nipt for adult onset conditions australian nipt users views |
| work_keys_str_mv | AT marksir niptforadultonsetconditionsaustralianniptusersviews AT devolderk niptforadultonsetconditionsaustralianniptusersviews AT bowmansmarth niptforadultonsetconditionsaustralianniptusersviews AT johnstonm niptforadultonsetconditionsaustralianniptusersviews AT millsc niptforadultonsetconditionsaustralianniptusersviews |