Stereoselectivity in the birch reduction of 2-furoic acid derivatives

The preparation and Birch reduction of chiral 3-methyl-2-furoic acid derivatives is described. Using a Ca symmetrical amine as a chiral auxiliary, very high levels of sterochemical control could be obtained. Moreover, the auxiliary could be removed conveniently by heating in 6M HCl to liberate a car...

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Autors principals: Donohoe, T, Helliwell, M, Stevenson, C, Ladduwahetty, T
Format: Journal article
Idioma:English
Publicat: 1998