Stereoselectivity in the birch reduction of 2-furoic acid derivatives

The preparation and Birch reduction of chiral 3-methyl-2-furoic acid derivatives is described. Using a Ca symmetrical amine as a chiral auxiliary, very high levels of sterochemical control could be obtained. Moreover, the auxiliary could be removed conveniently by heating in 6M HCl to liberate a car...

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Bibliografiska uppgifter
Huvudupphovsmän: Donohoe, T, Helliwell, M, Stevenson, C, Ladduwahetty, T
Materialtyp: Journal article
Språk:English
Publicerad: 1998