Combined familial C7 and C4B deficiency in an adult with meningococcal disease.
A case of meningococcal septicaemia is reported in an adult with a deficiency of the seventh component of complement combined with a deficiency of the B locus product of C4. A family study demonstrated that the two deficiencies were not linked. This is the first time that the individual alleles of C...
| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
1987
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| _version_ | 1826289730074968064 |
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| author | Chapel, H Peto, T Luzzi, G Thompson, R Fielder, A Batchelor, JR |
| author_facet | Chapel, H Peto, T Luzzi, G Thompson, R Fielder, A Batchelor, JR |
| author_sort | Chapel, H |
| collection | OXFORD |
| description | A case of meningococcal septicaemia is reported in an adult with a deficiency of the seventh component of complement combined with a deficiency of the B locus product of C4. A family study demonstrated that the two deficiencies were not linked. This is the first time that the individual alleles of C4 were determined in a patient with a deficiency of one component of the terminal pathway. It is possible that the heterogeneous clinical picture of a terminal pathway deficiency may, in part, be explained by the co-existence of other subtle complement defects. |
| first_indexed | 2024-03-07T02:33:20Z |
| format | Journal article |
| id | oxford-uuid:a7f88e84-2027-4a88-a1af-885f5b7de92d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:33:20Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:a7f88e84-2027-4a88-a1af-885f5b7de92d2022-03-27T02:58:10ZCombined familial C7 and C4B deficiency in an adult with meningococcal disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a7f88e84-2027-4a88-a1af-885f5b7de92dEnglishSymplectic Elements at Oxford1987Chapel, HPeto, TLuzzi, GThompson, RFielder, ABatchelor, JRA case of meningococcal septicaemia is reported in an adult with a deficiency of the seventh component of complement combined with a deficiency of the B locus product of C4. A family study demonstrated that the two deficiencies were not linked. This is the first time that the individual alleles of C4 were determined in a patient with a deficiency of one component of the terminal pathway. It is possible that the heterogeneous clinical picture of a terminal pathway deficiency may, in part, be explained by the co-existence of other subtle complement defects. |
| spellingShingle | Chapel, H Peto, T Luzzi, G Thompson, R Fielder, A Batchelor, JR Combined familial C7 and C4B deficiency in an adult with meningococcal disease. |
| title | Combined familial C7 and C4B deficiency in an adult with meningococcal disease. |
| title_full | Combined familial C7 and C4B deficiency in an adult with meningococcal disease. |
| title_fullStr | Combined familial C7 and C4B deficiency in an adult with meningococcal disease. |
| title_full_unstemmed | Combined familial C7 and C4B deficiency in an adult with meningococcal disease. |
| title_short | Combined familial C7 and C4B deficiency in an adult with meningococcal disease. |
| title_sort | combined familial c7 and c4b deficiency in an adult with meningococcal disease |
| work_keys_str_mv | AT chapelh combinedfamilialc7andc4bdeficiencyinanadultwithmeningococcaldisease AT petot combinedfamilialc7andc4bdeficiencyinanadultwithmeningococcaldisease AT luzzig combinedfamilialc7andc4bdeficiencyinanadultwithmeningococcaldisease AT thompsonr combinedfamilialc7andc4bdeficiencyinanadultwithmeningococcaldisease AT fieldera combinedfamilialc7andc4bdeficiencyinanadultwithmeningococcaldisease AT batchelorjr combinedfamilialc7andc4bdeficiencyinanadultwithmeningococcaldisease |