Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait.
About 10-15% of colorectal cancers show high-level microsatellite instability. The characteristics and very existence of low-level instability (MSI-L) are unclear, although some studies have found associations between MSI-L and molecular characteristics, notably more frequent K-ras mutations and a l...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2002
|
| _version_ | 1797087264762757120 |
|---|---|
| author | Halford, S Sasieni, P Rowan, A Wasan, H Bodmer, W Talbot, I Hawkins, N Ward, R Tomlinson, I |
| author_facet | Halford, S Sasieni, P Rowan, A Wasan, H Bodmer, W Talbot, I Hawkins, N Ward, R Tomlinson, I |
| author_sort | Halford, S |
| collection | OXFORD |
| description | About 10-15% of colorectal cancers show high-level microsatellite instability. The characteristics and very existence of low-level instability (MSI-L) are unclear, although some studies have found associations between MSI-L and molecular characteristics, notably more frequent K-ras mutations and a low level of allele loss near APC. We have attempted to define a MSI-L group of tumors by analyzing 107 sporadic colorectal carcinomas at 44 microsatellites. Ten (9.7%) MSI-H cancers were identified, but there was no evidence for a discrete MSI-L group. However, the 97 non-MSI-H cancers showed greater variation in the frequency of MSI than was expected by chance. Most cancers (68%) in the non-MSI-H group showed some MSI and could therefore be classed as nominally MSI-L. No association was found between MSI-L (or the level of MSI) and any clinicopathological or molecular variable, including K-ras mutation and loss of heterozygosity at APC. The causes of variation in level of the MSI in non-MSI-H colorectal cancers are unknown, but the differences are quantitative and probably reflect the evolutionary histories of the cancers rather than qualitatively different genetic pathways of tumorigenesis. |
| first_indexed | 2024-03-07T02:33:22Z |
| format | Journal article |
| id | oxford-uuid:a7fcca5e-fc0a-4175-9e9b-6f87bca3396f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:33:22Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:a7fcca5e-fc0a-4175-9e9b-6f87bca3396f2022-03-27T02:58:14ZLow-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a7fcca5e-fc0a-4175-9e9b-6f87bca3396fEnglishSymplectic Elements at Oxford2002Halford, SSasieni, PRowan, AWasan, HBodmer, WTalbot, IHawkins, NWard, RTomlinson, IAbout 10-15% of colorectal cancers show high-level microsatellite instability. The characteristics and very existence of low-level instability (MSI-L) are unclear, although some studies have found associations between MSI-L and molecular characteristics, notably more frequent K-ras mutations and a low level of allele loss near APC. We have attempted to define a MSI-L group of tumors by analyzing 107 sporadic colorectal carcinomas at 44 microsatellites. Ten (9.7%) MSI-H cancers were identified, but there was no evidence for a discrete MSI-L group. However, the 97 non-MSI-H cancers showed greater variation in the frequency of MSI than was expected by chance. Most cancers (68%) in the non-MSI-H group showed some MSI and could therefore be classed as nominally MSI-L. No association was found between MSI-L (or the level of MSI) and any clinicopathological or molecular variable, including K-ras mutation and loss of heterozygosity at APC. The causes of variation in level of the MSI in non-MSI-H colorectal cancers are unknown, but the differences are quantitative and probably reflect the evolutionary histories of the cancers rather than qualitatively different genetic pathways of tumorigenesis. |
| spellingShingle | Halford, S Sasieni, P Rowan, A Wasan, H Bodmer, W Talbot, I Hawkins, N Ward, R Tomlinson, I Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait. |
| title | Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait. |
| title_full | Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait. |
| title_fullStr | Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait. |
| title_full_unstemmed | Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait. |
| title_short | Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait. |
| title_sort | low level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait |
| work_keys_str_mv | AT halfords lowlevelmicrosatelliteinstabilityoccursinmostcolorectalcancersandisanonrandomlydistributedquantitativetrait AT sasienip lowlevelmicrosatelliteinstabilityoccursinmostcolorectalcancersandisanonrandomlydistributedquantitativetrait AT rowana lowlevelmicrosatelliteinstabilityoccursinmostcolorectalcancersandisanonrandomlydistributedquantitativetrait AT wasanh lowlevelmicrosatelliteinstabilityoccursinmostcolorectalcancersandisanonrandomlydistributedquantitativetrait AT bodmerw lowlevelmicrosatelliteinstabilityoccursinmostcolorectalcancersandisanonrandomlydistributedquantitativetrait AT talboti lowlevelmicrosatelliteinstabilityoccursinmostcolorectalcancersandisanonrandomlydistributedquantitativetrait AT hawkinsn lowlevelmicrosatelliteinstabilityoccursinmostcolorectalcancersandisanonrandomlydistributedquantitativetrait AT wardr lowlevelmicrosatelliteinstabilityoccursinmostcolorectalcancersandisanonrandomlydistributedquantitativetrait AT tomlinsoni lowlevelmicrosatelliteinstabilityoccursinmostcolorectalcancersandisanonrandomlydistributedquantitativetrait |