Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

Leptin and insulin have been identified as fuel sensors acting in part through their hypothalamic receptors to inhibit food intake and stimulate energy expenditure. As their intracellular signaling converges at the PI3K pathway, we directly addressed the role of phosphatidylinositol3,4,5-trisphospha...

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Bibliographic Details
Main Authors: Plum, L, Ma, X, Hampel, B, Balthasar, N, Coppari, R, Münzberg, H, Shanabrough, M, Burdakov, D, Rother, E, Janoschek, R, Alber, J, Belgardt, B, Koch, L, Seibler, J, Schwenk, F, Fekete, C, Suzuki, A, Mak, T, Krone, W, Horvath, T, Ashcroft, F, Brüning, J
Format: Journal article
Language:English
Published: 2006

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