Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar.

In mammalian systems, the heterodimeric basic helix-loop-helix (bHLH)-PAS transcription hypoxia-inducible factor (HIF) has emerged as the key regulator of responses to hypoxia. Here we define a homologous system in Drosophila melanogaster, and we characterize its activity in vivo during development....

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Detalles Bibliográficos
Autores principales: Lavista-Llanos, S, Centanin, L, Irisarri, M, Russo, D, Gleadle, J, Bocca, SN, Muzzopappa, M, Ratcliffe, P, Wappner, P
Formato: Journal article
Lenguaje:English
Publicado: 2002