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A novel interaction between the C5 and C8 domains of myosin binding protein-C and its modulation by HCM mutations

A novel interaction between the C5 and C8 domains of myosin binding protein-C and its modulation by HCM mutations

Dades bibliogràfiques
Autors principals: Flashman, E, Redwood, C, de Lange, T, Corfield, V, Moolman-Smook, J, Watkins, H
Format: Journal article
Publicat: 2002
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  • Interaction analyses elucidate the pathophysiology of HCM-causing missense mutations in cardiac myosin binding protein-C.
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  • Identification of novel interactions between domains of Myosin binding protein-C that are modulated by hypertrophic cardiomyopathy missense mutations.
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  • Cardiac myosin binding protein C: its role in physiology and disease.
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  • Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod.
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  • Support for a trimeric collar of myosin binding protein C in cardiac and fast, but not slow, skeletal muscle
    per: Moolman-Smook, J, et al.
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