Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice.

Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice.

BACKGROUND and AIMS: Transforming growth factor beta and its intracellular mediators, Smad proteins, play important roles in stimulating collagen gene transcription and, thus, could be the targets for treating hepatic fibrosis. However, intervention of transforming growth factor beta/Smad signaling...

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Bibliographic Details
Main Authors: Inagaki, Y, Kushida, M, Higashi, K, Itoh, J, Higashiyama, R, Hong, Y, Kawada, N, Namikawa, K, Kiyama, H, Bou-Gharios, G, Watanabe, T, Okazaki, I, Ikeda, K
Format: Journal article
Language:English
Published: 2005

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