Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice.

Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice.

BACKGROUND and AIMS: Transforming growth factor beta and its intracellular mediators, Smad proteins, play important roles in stimulating collagen gene transcription and, thus, could be the targets for treating hepatic fibrosis. However, intervention of transforming growth factor beta/Smad signaling...

Full description

Bibliographic Details
Main Authors:	Inagaki, Y, Kushida, M, Higashi, K, Itoh, J, Higashiyama, R, Hong, Y, Kawada, N, Namikawa, K, Kiyama, H, Bou-Gharios, G, Watanabe, T, Okazaki, I, Ikeda, K
Format:	Journal article
Language:	English
Published:	2005

Similar Items

Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice.
by: Higashiyama, R, et al.
Published: (2009)

Repression of collagen type I by TGF-beta induced CUX1
by: Fragiadaki, M, et al.
Published: (2010)

A novel TGF-beta response element located in the human collagen type I alpha 2 far upstream enhancer is SMAD-independent
by: Ponticos, M, et al.
Published: (2006)

Differential contribution of dermal resident and bone marrow-derived cells to collagen production during wound healing and fibrogenesis in mice.
by: Higashiyama, R, et al.
Published: (2011)

Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction.
by: Alexakis, C, et al.
Published: (2007)

High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1.
by: Fragiadaki, M, et al.
Published: (2011)

Role of TGF-Beta and Smad7 in Gut Inflammation, Fibrosis and Cancer
by: Carmine Stolfi, et al.
Published: (2020-12-01)

Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice
by: Yang Z, et al.
Published: (2023-06-01)

Bone marrow stem cells contribution to tissue fibrosis
by: Bou-Gharios, G
Published: (2006)

Isoliensinine Attenuates Renal Fibrosis and Inhibits TGF-β1/Smad2/3 Signaling Pathway in Spontaneously Hypertensive Rats
by: Yao M, et al.
Published: (2023-09-01)

SKIL/SnoN attenuates TGF-β1/SMAD signaling-dependent collagen synthesis in hepatic fibrosis
by: Cheng Chi, et al.
Published: (2023-11-01)

Organ-specific collagen expression: implications for renal disease.
by: Alexakis, C, et al.
Published: (2006)

Transcriptional regulation of the human alpha2(I) collagen gene
by: Antoniv, T, et al.
Published: (2006)

Wound-associated macrophages control collagen 1α2 transcription during the early stages of skin wound healing.
by: Rodero, M, et al.
Published: (2013)

JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction.
by: Ponticos, M, et al.
Published: (2009)

Oxoglaucine Suppresses Hepatic Fibrosis by Inhibiting TGFβ-Induced Smad2 Phosphorylation and ROS Generation
by: Bakhovuddin Azamov, et al.
Published: (2023-06-01)

Adiponectin Modified BMSCs Alleviate Heart Fibrosis via Inhibition TGF-beta1/Smad in Diabetic Rats
by: Ke Meng, et al.
Published: (2021-03-01)

AAV9-HGF cooperating with TGF-beta/Smad inhibitor attenuates silicosis fibrosis via inhibiting ferroptosis
by: Rui Bao, et al.
Published: (2023-05-01)

Repeated Intravenous Administration of Silica Nanoparticles Induces Pulmonary Inflammation and Collagen Accumulation via JAK2/STAT3 and TGF-β/Smad3 Pathways in vivo [Corrigendum]
by: Yu Y, et al.
Published: (2023-09-01)

Bone marrow-derived haematopoietic and mesenchymal stem cells colonise kidney but fail to produce collagen I in renal fibrosis
by: Roufosse, C, et al.
Published: (2006)

Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis.
by: Roufosse, C, et al.
Published: (2006)

Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.
by: Ponticos, M, et al.
Published: (2009)

Bone marrow-derived cells participate in renal regeneration but make a trivial contribution to collagen I synthesis in a murine model of kidney fibrosis
by: Roufosse, C, et al.
Published: (2005)

Corrigendum: Adiponectin modified BMSCs alleviate heart fibrosis via inhibition TGF-beta1/smad in diabetic rats
by: Ke Meng, et al.
Published: (2023-05-01)

High-Intensity Interval Training Attenuates Ketogenic Diet-Induced Liver Fibrosis in Type 2 Diabetic Mice by Ameliorating TGF-β1/Smad Signaling
by: Zhang Q, et al.
Published: (2020-11-01)

Transcriptional regulation of the human alpha2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseases.
by: Ramirez, F, et al.
Published: (2006)

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway
by: Mu M, et al.
Published: (2018-12-01)

Effects of T-lymphocyte depletion on muscle fibrosis in the mdx mouse.
by: Morrison, J, et al.
Published: (2005)

T-cell-dependent fibrosis in the mdx dystrophic mouse.
by: Morrison, J, et al.
Published: (2000)

CTGF Contributes to collagen type I expression in the bleomycin model of lung fibrosis and in human pulmonary fibroblasts by MAPK dependent transcriptional activation
by: Porticos, M, et al.
Published: (2009)

SIRT2 alleviated renal fibrosis by deacetylating SMAD2 and SMAD3 in renal tubular epithelial cells
by: Shu Yang, et al.
Published: (2023-09-01)

Renoprotective Effect of Formononetin by Suppressing Smad3 Expression in Db/Db Mice
by: Lv J, et al.
Published: (2020-09-01)

Molecular MRI of collagen to diagnose and stage liver fibrosis
by: Fuchs, Bryan C., et al.
Published: (2016)

FUNCTIONAL REGULATION OF FIBROSIS BY CUTL1 ISOFORMS
by: Ikeda, T, et al.
Published: (2009)

Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome.
by: Bevan, S, et al.
Published: (1999)

Distant mesenchymal progenitors contribute to skin wound healing and produce collagen: evidence from a murine fetal microchimerism model
by: Seppanen, E, et al.
Published: (2013)

Effect of echinacoside on kidney fibrosis by inhibition of TGF-β1/Smads signaling pathway in the db/db mice model of diabetic nephropathy
by: Tang FJ, et al.
Published: (2017-09-01)

TrxR/Trx inhibitor butaselen ameliorates pulmonary fibrosis by suppressing NF-κB/TGF-β1/Smads signaling
by: Yifan Chen, et al.
Published: (2023-12-01)

CXCR4 inhibition suppresses Cd-induced renal oxidative stress, apoptosis, and fibrosis by inhibiting the TGF-β1/Smad pathway
by: Yangbiao He, et al.
Published: (2023-04-01)

NON-INVASIVE IMAGING FOR THE ASSESSMENT OF DERMAL FIBROSIS
by: Jones, H, et al.
Published: (2010)