The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease.
Previous work has shown an association between the K variant of the butyrylcholinesterase (BCHE) gene and Alzheimer's disease (AD) in patients carrying the epsilon4 allele of ApoE. We attempted to replicate this finding in 181 UK white AD cases and 71 controls. No difference was found in BCHE-K...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
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1998
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| _version_ | 1826289805395230720 |
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| author | Kehoe, P Williams, H Holmans, P Wilcock, G Cairns, N Neal, J Owen, M |
| author_facet | Kehoe, P Williams, H Holmans, P Wilcock, G Cairns, N Neal, J Owen, M |
| author_sort | Kehoe, P |
| collection | OXFORD |
| description | Previous work has shown an association between the K variant of the butyrylcholinesterase (BCHE) gene and Alzheimer's disease (AD) in patients carrying the epsilon4 allele of ApoE. We attempted to replicate this finding in 181 UK white AD cases and 71 controls. No difference was found in BCHE-K genotypes (p=0.75) or alleles (p=0.70) between patients and controls. Moreover, despite a significant excess of ApoE epsilon4 in patients versus controls (p<0.0001), we found no evidence to support previous reports of an interaction between ApoE and BCHE-K (chi2=1.49, df=4, p=0.83). |
| first_indexed | 2024-03-07T02:34:30Z |
| format | Journal article |
| id | oxford-uuid:a856e24c-0b51-4127-b095-05a8a832c6fd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:34:30Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:a856e24c-0b51-4127-b095-05a8a832c6fd2022-03-27T03:00:48ZThe butyrylcholinesterase K variant and susceptibility to Alzheimer's disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a856e24c-0b51-4127-b095-05a8a832c6fdEnglishSymplectic Elements at Oxford1998Kehoe, PWilliams, HHolmans, PWilcock, GCairns, NNeal, JOwen, MPrevious work has shown an association between the K variant of the butyrylcholinesterase (BCHE) gene and Alzheimer's disease (AD) in patients carrying the epsilon4 allele of ApoE. We attempted to replicate this finding in 181 UK white AD cases and 71 controls. No difference was found in BCHE-K genotypes (p=0.75) or alleles (p=0.70) between patients and controls. Moreover, despite a significant excess of ApoE epsilon4 in patients versus controls (p<0.0001), we found no evidence to support previous reports of an interaction between ApoE and BCHE-K (chi2=1.49, df=4, p=0.83). |
| spellingShingle | Kehoe, P Williams, H Holmans, P Wilcock, G Cairns, N Neal, J Owen, M The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease. |
| title | The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease. |
| title_full | The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease. |
| title_fullStr | The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease. |
| title_full_unstemmed | The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease. |
| title_short | The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease. |
| title_sort | butyrylcholinesterase k variant and susceptibility to alzheimer s disease |
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