Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in Arabidopsis
Plant response to environmental stimuli involves integration of multiple signals. Upon low-oxygen stress, plants initiate a set of adaptive responses to circumvent an energy crisis. Here, we reveal how these stress responses are induced by combining (i) energy-dependent changes in the composition of...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
National Academy of Sciences
2018
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| _version_ | 1797087364454023168 |
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| author | Schmidt, RR Fulda, M Paul, MV Anders, M Plum, F Weits, DA Kosmacz, M Larson, TR Graham, IA Beemster, GTS Licausi, F Geigenberger, P Schippers, JH van Dongen, JT |
| author_facet | Schmidt, RR Fulda, M Paul, MV Anders, M Plum, F Weits, DA Kosmacz, M Larson, TR Graham, IA Beemster, GTS Licausi, F Geigenberger, P Schippers, JH van Dongen, JT |
| author_sort | Schmidt, RR |
| collection | OXFORD |
| description | Plant response to environmental stimuli involves integration of multiple signals. Upon low-oxygen stress, plants initiate a set of adaptive responses to circumvent an energy crisis. Here, we reveal how these stress responses are induced by combining (i) energy-dependent changes in the composition of the acyl-CoA pool and (ii) the cellular oxygen concentration. A hypoxia-induced decline of cellular ATP levels reduces LONG-CHAIN ACYL-COA SYNTHETASE activity, which leads to a shift in the composition of the acyl-CoA pool. Subsequently, we show that different acyl-CoAs induce unique molecular responses. Altogether, our data disclose a role for acyl-CoAs acting in a cellular signaling pathway in plants. Upon hypoxia, high oleoyl-CoA levels provide the initial trigger to release the transcription factor RAP2.12 from its interaction partner ACYL-COA BINDING PROTEIN at the plasma membrane. Subsequently, according to the N-end rule for proteasomal degradation, oxygen concentration-dependent stabilization of the subgroup VII ETHYLENE-RESPONSE FACTOR transcription factor RAP2.12 determines the level of hypoxia-specific gene expression. This research unveils a specific mechanism activating low-oxygen stress responses only when a decrease in the oxygen concentration coincides with a drop in energy. |
| first_indexed | 2024-03-07T02:34:40Z |
| format | Journal article |
| id | oxford-uuid:a8635b49-595f-46df-ad4a-9f61206f0b2b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:34:40Z |
| publishDate | 2018 |
| publisher | National Academy of Sciences |
| record_format | dspace |
| spelling | oxford-uuid:a8635b49-595f-46df-ad4a-9f61206f0b2b2022-03-27T03:01:15ZLow-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in ArabidopsisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a8635b49-595f-46df-ad4a-9f61206f0b2bEnglishSymplectic ElementsNational Academy of Sciences2018Schmidt, RRFulda, MPaul, MVAnders, MPlum, FWeits, DAKosmacz, MLarson, TRGraham, IABeemster, GTSLicausi, FGeigenberger, PSchippers, JHvan Dongen, JTPlant response to environmental stimuli involves integration of multiple signals. Upon low-oxygen stress, plants initiate a set of adaptive responses to circumvent an energy crisis. Here, we reveal how these stress responses are induced by combining (i) energy-dependent changes in the composition of the acyl-CoA pool and (ii) the cellular oxygen concentration. A hypoxia-induced decline of cellular ATP levels reduces LONG-CHAIN ACYL-COA SYNTHETASE activity, which leads to a shift in the composition of the acyl-CoA pool. Subsequently, we show that different acyl-CoAs induce unique molecular responses. Altogether, our data disclose a role for acyl-CoAs acting in a cellular signaling pathway in plants. Upon hypoxia, high oleoyl-CoA levels provide the initial trigger to release the transcription factor RAP2.12 from its interaction partner ACYL-COA BINDING PROTEIN at the plasma membrane. Subsequently, according to the N-end rule for proteasomal degradation, oxygen concentration-dependent stabilization of the subgroup VII ETHYLENE-RESPONSE FACTOR transcription factor RAP2.12 determines the level of hypoxia-specific gene expression. This research unveils a specific mechanism activating low-oxygen stress responses only when a decrease in the oxygen concentration coincides with a drop in energy. |
| spellingShingle | Schmidt, RR Fulda, M Paul, MV Anders, M Plum, F Weits, DA Kosmacz, M Larson, TR Graham, IA Beemster, GTS Licausi, F Geigenberger, P Schippers, JH van Dongen, JT Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in Arabidopsis |
| title | Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in Arabidopsis |
| title_full | Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in Arabidopsis |
| title_fullStr | Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in Arabidopsis |
| title_full_unstemmed | Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in Arabidopsis |
| title_short | Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in Arabidopsis |
| title_sort | low oxygen response is triggered by an atp dependent shift in oleoyl coa in arabidopsis |
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