Synchronisation in the beta frequency-band--the bad boy of parkinsonism or an innocent bystander?
Excessive synchronisation of basal ganglia neuronal activity in the beta frequency band has been implicated in Parkinson's disease. In a recent issue of Experimental Neurology, Bronte-Stewart, H., Barberini, C., Koop, M.M., Hill, B.C., Henderson, J.M., Wingeier, B., 2009. The STN beta-band prof...
| Glavni autori: | , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2009
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| _version_ | 1826289820878503936 |
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| author | Eusebio, A Brown, P |
| author_facet | Eusebio, A Brown, P |
| author_sort | Eusebio, A |
| collection | OXFORD |
| description | Excessive synchronisation of basal ganglia neuronal activity in the beta frequency band has been implicated in Parkinson's disease. In a recent issue of Experimental Neurology, Bronte-Stewart, H., Barberini, C., Koop, M.M., Hill, B.C., Henderson, J.M., Wingeier, B., 2009. The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain stimulation. Exp. Neurol. 215, 20-28. demonstrate that such activity is consistent over time and provide further evidence that deep brain stimulation is associated with its suppression. However, the extent to which beta synchrony has a mechanistic (rather than epiphenomenal) role in parkinsonism remains unclear, and the suppression of this activity by deep brain stimulation is contentious. This commentary discusses the evidence for and against a role for excessive beta synchrony in mediating the parkinsonian phenotype and in providing a possible mechanism to explain the therapeutic effects of deep brain stimulation in Parkinson's disease. |
| first_indexed | 2024-03-07T02:34:44Z |
| format | Journal article |
| id | oxford-uuid:a86a4149-40e4-4b2c-95f9-380d89c08ec0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:34:44Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:a86a4149-40e4-4b2c-95f9-380d89c08ec02022-03-27T03:01:22ZSynchronisation in the beta frequency-band--the bad boy of parkinsonism or an innocent bystander?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a86a4149-40e4-4b2c-95f9-380d89c08ec0EnglishSymplectic Elements at Oxford2009Eusebio, ABrown, PExcessive synchronisation of basal ganglia neuronal activity in the beta frequency band has been implicated in Parkinson's disease. In a recent issue of Experimental Neurology, Bronte-Stewart, H., Barberini, C., Koop, M.M., Hill, B.C., Henderson, J.M., Wingeier, B., 2009. The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain stimulation. Exp. Neurol. 215, 20-28. demonstrate that such activity is consistent over time and provide further evidence that deep brain stimulation is associated with its suppression. However, the extent to which beta synchrony has a mechanistic (rather than epiphenomenal) role in parkinsonism remains unclear, and the suppression of this activity by deep brain stimulation is contentious. This commentary discusses the evidence for and against a role for excessive beta synchrony in mediating the parkinsonian phenotype and in providing a possible mechanism to explain the therapeutic effects of deep brain stimulation in Parkinson's disease. |
| spellingShingle | Eusebio, A Brown, P Synchronisation in the beta frequency-band--the bad boy of parkinsonism or an innocent bystander? |
| title | Synchronisation in the beta frequency-band--the bad boy of parkinsonism or an innocent bystander? |
| title_full | Synchronisation in the beta frequency-band--the bad boy of parkinsonism or an innocent bystander? |
| title_fullStr | Synchronisation in the beta frequency-band--the bad boy of parkinsonism or an innocent bystander? |
| title_full_unstemmed | Synchronisation in the beta frequency-band--the bad boy of parkinsonism or an innocent bystander? |
| title_short | Synchronisation in the beta frequency-band--the bad boy of parkinsonism or an innocent bystander? |
| title_sort | synchronisation in the beta frequency band the bad boy of parkinsonism or an innocent bystander |
| work_keys_str_mv | AT eusebioa synchronisationinthebetafrequencybandthebadboyofparkinsonismoraninnocentbystander AT brownp synchronisationinthebetafrequencybandthebadboyofparkinsonismoraninnocentbystander |