Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.

Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.

Mouse beta-cells cultured at 15 mmol/l glucose for 72 h had reduced ATP-sensitive K+ (K(ATP)) channel activity (-30%), increased voltage-gated Ca2+ currents, higher intracellular free Ca2+ concentration ([Ca2+]i; +160%), more exocytosis (monitored by capacitance measurements, +100%), and greater ins...

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Autors principals:	Olofsson, C, Collins, S, Bengtsson, M, Eliasson, L, Salehi, A, Shimomura, K, Tarasov, A, Holm, C, Ashcroft, F, Rorsman, P
Format:	Journal article
Idioma:	English
Publicat:	2007

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