Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites
γ-Aminobutyric acid receptors (GABAARs) are vital for controlling excitability in the brain. This is emphasized by the numerous neuropsychiatric disorders that result from receptor dysfunction. A critical component of most native GABAARs is the α subunit. Its transmembrane domain is the target for m...
Main Authors: | Laverty, D, Thomas, P, Field, M, Andersen, OJ, Gold, MG, Biggin, PC, Gielen, M, Smart, TG |
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Format: | Journal article |
Language: | English |
Published: |
Nature Research
2017
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