Solubilized pancreatic extracellular matrix from juvenile pigs protects isolated human islets from hypoxia-induced damage: a viable option for clinical islet transplantation

Solubilized pancreatic extracellular matrix from juvenile pigs protects isolated human islets from hypoxia-induced damage: a viable option for clinical islet transplantation

The pancreatic extracellular matrix (ECM) is an enormously complex construct. Previous studies underline the challenges to identify the optimal combinations and ratios of individual ECM proteins for promoting survival and function of isolated and transplanted islets. This study aimed on assessing th...

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Bibliografiske detaljer
Main Authors:	Brandhorst, H, Krishtul, S, Brandhorst, D, Baruch, L, Machluf, M, Johnson, PRV
Format:	Journal article
Sprog:	English
Udgivet:	Hindawi Publishing Corporation 2023

Lignende værker

Pancreatic islets: methods for isolation and purification of juvenile and adult pig islets
af: Brandhorst, H, et al.
Udgivet: (2016)

Basement membrane proteins improve human islet survival in hypoxia: Implications for islet inflammation
af: Brandhorst, D, et al.
Udgivet: (2021)

The ischaemic preconditioning paradox and its implications for islet isolation from heart-beating and non heart-beating donors
af: Brandhorst, D, et al.
Udgivet: (2022)

Pig Pancreas Oxygenation at 20°C Increases Islet ATP Generation but Deteriorates Islet Function
af: M. Iken, et al.
Udgivet: (2009-07-01)

High concentrations of Etanercept reduce human islet function and integrity
af: Brandhorst, D, et al.
Udgivet: (2021)

High Concentrations of Etanercept Reduce Human Islet Function and Integrity
af: Brandhorst D, et al.
Udgivet: (2021-02-01)

Pig pancreas oxygenation at 20 degrees C increases islet ATP generation but deteriorates islet function.
af: Iken, M, et al.
Udgivet: (2009)

Pretransplant induction of HSP-70 in isolated adult pig islets decreases early islet xenograft survival.
af: Brandhorst, D, et al.
Udgivet: (2000)

Pancreatic L-Glutamine Administration Protects Pig Islets from Cold Ischemic Injury and Increases Resistance toward Inflammatory Mediators
af: Brandhorst, H, et al.
Udgivet: (2016)

Pancreatic L-Glutamine Administration Protects Pig Islets from Cold Ischemic Injury and Increases Resistance toward Inflammatory Mediators
af: Heide Brandhorst, et al.
Udgivet: (2016-03-01)

Pretransplant Induction of HSP-70 in Isolated Adult Pig Islets Decreases Early Islet Xenograft Survival
af: Daniel Brandhorst Ph.D., et al.
Udgivet: (2000-05-01)

Heat-exposed pig islets are protected from inflammatory mediators but express proapoptotic proteins.
af: Brandhorst, D, et al.
Udgivet: (2003)

Prevention of early islet graft failure by selective inducible nitric oxide synthase inhibitors after pig to nude rat intraportal islet transplantation.
af: Brandhorst, D, et al.
Udgivet: (2001)

Ischaemia is linked to inflammation and induction of angiogenesis in pancreatic islets.
af: Linn, T, et al.
Udgivet: (2006)

Strategies to improve the oxygen supply to microencapsulated islets
af: Brandhorst, D, et al.
Udgivet: (2019)

Activation of NFκB dependent apoptotic pathway in pancreatic islet cells by hypoxia.
af: Lai, Y, et al.
Udgivet: (2009)

High seeding density induces local hypoxia and triggers a proinflammatory response in isolated human islets
af: Brandhorst, D, et al.
Udgivet: (2016)

Hypoxia-induced damage in human islets is reduced with the use of mesenchymal stem cell-preconditioned medium
af: Brandhorst, D, et al.
Udgivet: (2017)

Adaption of neutral protease activity for islet isolation from the long-term two-layer method-stored pig pancreas.
af: Brandhorst, D, et al.
Udgivet: (2005)

Hyperthermic preconditioning protects pig islet grafts from early inflammation but enhances rejection in immunocompetent mice.
af: Brandhorst, D, et al.
Udgivet: (2003)

Long-term preservation of the pig pancreas by a one-layer method for successful islet isolation.
af: Brandhorst, D, et al.
Udgivet: (2005)

Induction and amelioration of environmental stress in isolated islets until transplantation
af: Brandhorst, D, et al.
Udgivet: (2006)

Proteomic profiling reveals the ambivalent character of the mesenchymal stem cell secretome: assessing the effect of preconditioned media on isolated human islets
af: Brandhorst, H, et al.
Udgivet: (2020)

Expression of complement regulatory proteins on islets of Langerhans: a comparison between human islets and islets isolated from normal and hDAF transgenic pigs.
af: Bennet, W, et al.
Udgivet: (2001)

Can the density of native pancreatic tissue slices predict human islet isolation and purification outcome?
af: Eckhard, M, et al.
Udgivet: (2004)

Effect of etanercept concentration on human islet integrity
af: Acreman, S, et al.
Udgivet: (2017)

Successful pancreas preservation by a perfluorocarbon-based one-layer method for subsequent pig islet isolation.
af: Brandhorst, D, et al.
Udgivet: (2005)

High Seeding Density Induces Local Hypoxia and Triggers a Proinflammatory Response in Isolated Human Islets
af: Daniel Brandhorst, et al.
Udgivet: (2016-08-01)

Hyperthermic Preconditioning Protects Pig Islet Grafts from Early Inflammation but Enhances Rejection in Immunocompetent Mice
af: Daniel Brandhorst Ph.D., et al.
Udgivet: (2003-11-01)

High-dosed nicotinamide decreases early graft failure after pig to nude rat intraportal islet transplantation.
af: Brandhorst, D, et al.
Udgivet: (2002)

Prevention of intraportal islet failure by a highly selective iNOS inhibitor in the pig-to-nude rat model.
af: Brandhorst, D, et al.
Udgivet: (2001)

Enzyme development for human islet isolation: Five decades of progress or stagnation?
af: Brandhorst, D, et al.
Udgivet: (2017)

Pancreas storage in oxygenated perfluorodecalin does not restore post-transplant function of isolated pig islets pre-damaged by warm ischemia.
af: Brandhorst, D, et al.
Udgivet: (2006)

Quantifying the effects of different neutral proteases on human islet integrity
af: Brandhorst, H, et al.
Udgivet: (2018)

Effect of stable glutamine compounds on porcine islet culture.
af: Brandhorst, H, et al.
Udgivet: (2005)

Degraded collagenase deteriorates islet viability.
af: Brandhorst, H, et al.
Udgivet: (2008)

Influence of collagenase loading on long-term preservation of pig pancreas by the two-layer method for subsequent islet isolation.
af: Brandhorst, D, et al.
Udgivet: (2005)

Does islet size really influence graft function following clinical islet transplantation?
af: Hughes, S, et al.
Udgivet: (2018)

Timing of hyperthermic preconditioning affects islet resistance against inflammation.
af: Brandhorst, D, et al.
Udgivet: (2005)

Influence of neutral protease activity on human islet isolation outcome.
af: Brandhorst, H, et al.
Udgivet: (2005)