Delivery of siRNA mediated by histidine-containing reducible polycations.

Delivery of siRNA mediated by histidine-containing reducible polycations.

Histidine containing reducible polycations based on CH(6)K(3)H(6)C monomers (His6 RPCs), are highly effective DNA transfection agents combining pH buffering endosomal escape mechanisms with rapid unpackaging following reduction in the cytoplasm. We examined their ability to mediate siRNA uptake into...

书目详细资料
Main Authors:	Stevenson, M, Ramos-Perez, V, Singh, S, Soliman, M, Preece, J, Briggs, S, Read, M, Seymour, L
格式:	Journal article
语言:	English
出版:	2008

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