Aetiologies of central nervous system infections in adults in Kathmandu, Nepal: a prospective hospital-based study
We conducted a prospective hospital based study from February 2009-April 2011 to identify the possible pathogens of central nervous system (CNS) infections in adults admitted to a tertiary referral hospital (Patan Hospital) in Kathmandu, Nepal. The pathogens of CNS infections were confirmed in cereb...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2013
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| _version_ | 1797087466430136320 |
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| author | Giri, A Arjyal, A Koirala, S Karkey, A Dongol, S Thapa, S Shilpakar, O Shrestha, R Van Tan, L Thi Thuy Chinh, B Krishna K C, R Pathak, K Shakya, M Farrar, J Van Doorn, H Basnyat, B |
| author_facet | Giri, A Arjyal, A Koirala, S Karkey, A Dongol, S Thapa, S Shilpakar, O Shrestha, R Van Tan, L Thi Thuy Chinh, B Krishna K C, R Pathak, K Shakya, M Farrar, J Van Doorn, H Basnyat, B |
| author_sort | Giri, A |
| collection | OXFORD |
| description | We conducted a prospective hospital based study from February 2009-April 2011 to identify the possible pathogens of central nervous system (CNS) infections in adults admitted to a tertiary referral hospital (Patan Hospital) in Kathmandu, Nepal. The pathogens of CNS infections were confirmed in cerebrospinal fluid (CSF) using molecular diagnostics, culture (bacteria) and serology. 87 patients were recruited for the study and the etiological diagnosis was established in 38% (n = 33). The bacterial pathogens identified were Neisseria meningitidis (n = 6); Streptococcus pneumoniae (n = 5) and Staphylococcus aureus (n = 2) in 13/87(14%). Enteroviruses were found in 12/87 (13%); Herpes Simplex virus (HSV) in 2/87(2%). IgM against Japanese encephalitis virus (JEV) was detected in the CSF of 11/73 (15%) tested samples. This is the first prospective molecular and serology based CSF analysis in adults with CNS infections in Kathmandu, Nepal. JEV and enteroviruses were the most commonly detected pathogens in this setting. |
| first_indexed | 2024-03-07T02:36:05Z |
| format | Journal article |
| id | oxford-uuid:a8d9f42a-489c-46af-be46-64f8a35878bb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:36:05Z |
| publishDate | 2013 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:a8d9f42a-489c-46af-be46-64f8a35878bb2022-03-27T03:04:22ZAetiologies of central nervous system infections in adults in Kathmandu, Nepal: a prospective hospital-based studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a8d9f42a-489c-46af-be46-64f8a35878bbEnglishSymplectic Elements at OxfordSpringer Nature2013Giri, AArjyal, AKoirala, SKarkey, ADongol, SThapa, SShilpakar, OShrestha, RVan Tan, LThi Thuy Chinh, BKrishna K C, RPathak, KShakya, MFarrar, JVan Doorn, HBasnyat, BWe conducted a prospective hospital based study from February 2009-April 2011 to identify the possible pathogens of central nervous system (CNS) infections in adults admitted to a tertiary referral hospital (Patan Hospital) in Kathmandu, Nepal. The pathogens of CNS infections were confirmed in cerebrospinal fluid (CSF) using molecular diagnostics, culture (bacteria) and serology. 87 patients were recruited for the study and the etiological diagnosis was established in 38% (n = 33). The bacterial pathogens identified were Neisseria meningitidis (n = 6); Streptococcus pneumoniae (n = 5) and Staphylococcus aureus (n = 2) in 13/87(14%). Enteroviruses were found in 12/87 (13%); Herpes Simplex virus (HSV) in 2/87(2%). IgM against Japanese encephalitis virus (JEV) was detected in the CSF of 11/73 (15%) tested samples. This is the first prospective molecular and serology based CSF analysis in adults with CNS infections in Kathmandu, Nepal. JEV and enteroviruses were the most commonly detected pathogens in this setting. |
| spellingShingle | Giri, A Arjyal, A Koirala, S Karkey, A Dongol, S Thapa, S Shilpakar, O Shrestha, R Van Tan, L Thi Thuy Chinh, B Krishna K C, R Pathak, K Shakya, M Farrar, J Van Doorn, H Basnyat, B Aetiologies of central nervous system infections in adults in Kathmandu, Nepal: a prospective hospital-based study |
| title | Aetiologies of central nervous system infections in adults in Kathmandu, Nepal: a prospective hospital-based study |
| title_full | Aetiologies of central nervous system infections in adults in Kathmandu, Nepal: a prospective hospital-based study |
| title_fullStr | Aetiologies of central nervous system infections in adults in Kathmandu, Nepal: a prospective hospital-based study |
| title_full_unstemmed | Aetiologies of central nervous system infections in adults in Kathmandu, Nepal: a prospective hospital-based study |
| title_short | Aetiologies of central nervous system infections in adults in Kathmandu, Nepal: a prospective hospital-based study |
| title_sort | aetiologies of central nervous system infections in adults in kathmandu nepal a prospective hospital based study |
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