Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells.

Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells.

Somatostatin hyperpolarized rat pancreatic alpha-cells and inhibited spontaneous electrical activity by activating a low-conductance K+ channel (0.9 pS with physiological ionic gradients). This channel was insensitive to tolbutamide (a blocker of ATP-sensitive K+ channels) and apamin (an inhibitor o...

Полное описание

Библиографические подробности
Главные авторы:	Gromada, J, Høy, M, Olsen, H, Gotfredsen, C, Buschard, K, Rorsman, P, Bokvist, K
Формат:	Journal article
Язык:	English
Опубликовано:	2001

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