Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells.

Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells.

Somatostatin hyperpolarized rat pancreatic alpha-cells and inhibited spontaneous electrical activity by activating a low-conductance K+ channel (0.9 pS with physiological ionic gradients). This channel was insensitive to tolbutamide (a blocker of ATP-sensitive K+ channels) and apamin (an inhibitor o...

書目詳細資料
Main Authors:	Gromada, J, Høy, M, Olsen, H, Gotfredsen, C, Buschard, K, Rorsman, P, Bokvist, K
格式:	Journal article
語言:	English
出版:	2001

相似書籍

G(i2) proteins couple somatostatin receptors to K+-channel activity and exocytosis in glucagon secreting rat A-cells
由: Gromada, J, et al.
出版: (1999)

Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells.
由: Bokvist, K, et al.
出版: (1999)

Does the K-ATP channel participate in the regulation of glucagon secretion?
由: Bokvist, K, et al.
出版: (1999)

Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial-like ATP-sensitive K+ (KATP) conductance in rat pancreatic A-cells.
由: Høy, M, et al.
出版: (2000)

Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules.
由: Gromada, J, et al.
出版: (2001)

Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells.
由: Høy, M, et al.
出版: (2003)

Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K channels and stimulation of cyclic AMP-dependent exocytosis.
由: Gromada, J, et al.
出版: (2002)

ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.
由: Gromada, J, et al.
出版: (2004)

Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels.
由: Gromada, J, et al.
出版: (1997)

Adrenaline stimulates secretion in rat pancreatic alpha-cells by PKA-dependent acceleration of Ca2+ influx through 1-type Ca2+- channels
由: Gromada, J, et al.
出版: (1996)

A NOVEL LOW-CONDUCTANCE K+-CHANNEL PRODUCING MEMBRANE-POTENTIAL OSCILLATIONS IN MOUSE PANCREATIC BETA-CELLS
由: Bokvist, K, et al.
出版: (1992)

Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells.
由: Rorsman, P, et al.
出版: (1991)

Effects of external tetraethylammonium ions and quinine on delayed rectifying K+ channels in mouse pancreatic beta-cells.
由: Bokvist, K, et al.
出版: (1990)

Acetylcholine stimulates exocytosis by acceleration of granula mobilisation in mouse pancreatic B-cells
由: Gromada, J, et al.
出版: (1998)

Inhibition of ATP-regulated K(+)-channels by a photoactivatable ATP-analogue in mouse pancreatic beta-cells.
由: Ammälä, C, et al.
出版: (1991)

Block of ATP-regulated and Ca2(+)-activated K+ channels in mouse pancreatic beta-cells by external tetraethylammonium and quinine.
由: Bokvist, K, et al.
出版: (1990)

Nateglinide, but not repaglinide, stimulates growth hormone secretion from rat pituitary cells.
由: Bokvist, K, et al.
出版: (2000)

Alpha 2-adrenoreceptor stimulation does not inhibit L-type calcium channels in mouse pancreatic beta-cells.
由: Bokvist, K, et al.
出版: (1991)

Compound exocytosis in voltage-clamped mouse pancreatic beta-cells revealed by carbon fibre amperometry.
由: Bokvist, K, et al.
出版: (2000)

CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells.
由: Gromada, J, et al.
出版: (1999)

Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.
由: Ma, X, et al.
出版: (2005)

Demonstration of a novel apamin-insensitive calcium-activated K+ channel in mouse pancreatic B cells.
由: Ammälä, C, et al.
出版: (1993)

Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling.
由: Gromada, J, et al.
出版: (1998)

Somatostatin but not insulin is an important paracrine regulator of glucagon secretion in rat A-cells
由: Renstrom, E, et al.
出版: (1997)

ATP-REGULATED K+ CHANNELS AND DIABETES-MELLITUS
由: Rorsman, P, et al.
出版: (1990)

Delayed rectifying and calcium-activated K+ channels and their significance for action potential repolarization in mouse pancreatic beta-cells.
由: Smith, P, et al.
出版: (1990)

The somatostatin-secreting pancreatic δ-cell in health and disease
由: Rorsman, P, et al.
出版: (2018)

Glucagon-like peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat alpha-cells by a protein kinase A-mediated mechanism.
由: Ding, W, et al.
出版: (1997)

Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K(+)-channels in mouse pancreatic beta-cells.
由: Bokvist, K, et al.
出版: (1991)

Significance of Na/Ca exchange for Ca2+ buffering and electrical activity in mouse pancreatic beta-cells.
由: Gall, D, et al.
出版: (1999)

Stimulus-secretion coupling in pancreatic beta cells.
由: Ashcroft, F, et al.
出版: (1994)

Inhibition of L-type calcium channels by internal GTP [gamma S] in mouse pancreatic beta cells.
由: Ammälä, C, et al.
出版: (1992)

GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin.
由: Braun, M, et al.
出版: (2004)

Inositol trisphosphate-dependent periodic activation of a Ca(2+)-activated K+ conductance in glucose-stimulated pancreatic beta-cells.
由: Ammälä, C, et al.
出版: (1991)

Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets.
由: Göpel, S, et al.
出版: (2000)

Does galanin inhibit insulin secretion by opening of the ATP-regulated K+ channel in the beta-cell?
由: Ahrén, B, et al.
出版: (1989)

Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells.
由: Olsen, H, et al.
出版: (2003)

Stimulation of the KATP channel by ADP and diazoxide requires nucleotide hydrolysis in mouse pancreatic beta-cells.
由: Larsson, O, et al.
出版: (1993)

Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.
由: Wendt, A, et al.
出版: (2004)

Demonstration of A-currents in pancreatic islet cells.
由: Smith, P, et al.
出版: (1989)