Metabolic checkpoints in rheumatoid arthritis
Several studies have highlighted the interplay between metabolism, immunity and inflammation. Both tissue resident and infiltrating immune cells play a major role in the inflammatory process of rheumatoid arthritis (RA) via the production of cytokines, adipocytokines and metabolic intermediates. The...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Frontiers Media
2020
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| _version_ | 1797087483318501376 |
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| author | Pucino, V Certo, M Varricchi, G Marone, G Ursini, F Rossi, FW De Paulis, A Mauro, C Raza, K Buckley, CD |
| author_facet | Pucino, V Certo, M Varricchi, G Marone, G Ursini, F Rossi, FW De Paulis, A Mauro, C Raza, K Buckley, CD |
| author_sort | Pucino, V |
| collection | OXFORD |
| description | Several studies have highlighted the interplay between metabolism, immunity and
inflammation. Both tissue resident and infiltrating immune cells play a major role in the
inflammatory process of rheumatoid arthritis (RA) via the production of cytokines, adipocytokines and metabolic intermediates. These functions are metabolically demanding
and require the most efficient use of bioenergetic pathways. The synovial membrane
is the primary site of inflammation in RA and exhibits distinctive histological patterns
characterized by different metabolism, prognosis and response to treatment. In the
RA synovium, the high energy demand by stromal and infiltrating immune cells,
causes the accumulation of metabolites, and adipo-cytokines, which carry out signaling
functions, as well as activating transcription factors which act as metabolic sensors.
These events drive immune and joint-resident cells to acquire pro-inflammatory effector
functions which in turn perpetuate chronic inflammation. Whether metabolic changes
are a consequence of the disease or one of the causes of RA pathogenesis is still
under investigation. This review covers our current knowledge of cell metabolism in
RA. Understanding the intricate interactions between metabolic pathways and the
inflammatory and immune responses will provide more awareness of the mechanisms
underlying RA pathogenesis and will identify novel therapeutic options to treat
this disease.
|
| first_indexed | 2024-03-07T02:36:17Z |
| format | Journal article |
| id | oxford-uuid:a8e6bed0-912f-4dc2-8436-6c22bfe8c4e1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:36:17Z |
| publishDate | 2020 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:a8e6bed0-912f-4dc2-8436-6c22bfe8c4e12022-03-27T03:04:46ZMetabolic checkpoints in rheumatoid arthritisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a8e6bed0-912f-4dc2-8436-6c22bfe8c4e1EnglishSymplectic ElementsFrontiers Media2020Pucino, VCerto, MVarricchi, GMarone, GUrsini, FRossi, FWDe Paulis, AMauro, CRaza, KBuckley, CDSeveral studies have highlighted the interplay between metabolism, immunity and inflammation. Both tissue resident and infiltrating immune cells play a major role in the inflammatory process of rheumatoid arthritis (RA) via the production of cytokines, adipocytokines and metabolic intermediates. These functions are metabolically demanding and require the most efficient use of bioenergetic pathways. The synovial membrane is the primary site of inflammation in RA and exhibits distinctive histological patterns characterized by different metabolism, prognosis and response to treatment. In the RA synovium, the high energy demand by stromal and infiltrating immune cells, causes the accumulation of metabolites, and adipo-cytokines, which carry out signaling functions, as well as activating transcription factors which act as metabolic sensors. These events drive immune and joint-resident cells to acquire pro-inflammatory effector functions which in turn perpetuate chronic inflammation. Whether metabolic changes are a consequence of the disease or one of the causes of RA pathogenesis is still under investigation. This review covers our current knowledge of cell metabolism in RA. Understanding the intricate interactions between metabolic pathways and the inflammatory and immune responses will provide more awareness of the mechanisms underlying RA pathogenesis and will identify novel therapeutic options to treat this disease. |
| spellingShingle | Pucino, V Certo, M Varricchi, G Marone, G Ursini, F Rossi, FW De Paulis, A Mauro, C Raza, K Buckley, CD Metabolic checkpoints in rheumatoid arthritis |
| title | Metabolic checkpoints in rheumatoid arthritis |
| title_full | Metabolic checkpoints in rheumatoid arthritis |
| title_fullStr | Metabolic checkpoints in rheumatoid arthritis |
| title_full_unstemmed | Metabolic checkpoints in rheumatoid arthritis |
| title_short | Metabolic checkpoints in rheumatoid arthritis |
| title_sort | metabolic checkpoints in rheumatoid arthritis |
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