A common variant near TGFBR3 is associated with primary open angle glaucoma
Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 co...
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| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
Oxford University Press
2015
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| _version_ | 1826289945616056320 |
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| author | Li, Z Allingham, R Nakano, M Jia, L Chen, Y Ikeda, Y Mani, B Chen, L Kee, C Garway-Heath, D Sripriya, S Fuse, N Abu-Amero, K Huang, C Namburi, P Burdon, K Perera, S Gharahkhani, P Lin, Y Ueno, M Ozaki, M Mizoguchi, T Krishnadas, S Osman, E Lee, M Chan, A Tajudin, L Do, T Goncalves, A Reynier, P Zhang, H Bourne, R Goh, D Broadway, D Husain, R Negi, A Su, D Ho, C Blanco, A Leung, C Wong, T Yakub, A Liu, Y Nongpiur, M Han, J Hon, D Shantha, B Zhao, B Sang, J Zhang, N Sato, R Yoshii, K Panda-Jonas, S Ashley Koch, A Herndon, L Moroi, S Challa, P Foo, J Bei, J Zeng, Y Simmons, C Bich Chau, T Sharmila, P Chew, M Lim, B Tam, P Chua, E Ng, X Yong, V Chong, Y Meah, W Vijayan, S Seongsoo, S Xu, W Teo, Y Cooke Bailey, J Kang, J Haines, J Cheng, C Saw, S Tai, E Richards, J Ritch, R Gaasterland, D Pasquale, L Liu, J Jonas, J Milea, D George, R Al-Obeidan, S Mori, K Macgregor, S Hewitt, A Girkin, C Zhang, M Sundaresan, P Vijaya, L Mackey, D Wong, T Craig, J Sun, X Kinoshita, S Wiggs, J Khor, C Yang, Z Pang, C Wang, N Hauser, M Tashiro, K Aung, T Vithana, E |
| author_facet | Li, Z Allingham, R Nakano, M Jia, L Chen, Y Ikeda, Y Mani, B Chen, L Kee, C Garway-Heath, D Sripriya, S Fuse, N Abu-Amero, K Huang, C Namburi, P Burdon, K Perera, S Gharahkhani, P Lin, Y Ueno, M Ozaki, M Mizoguchi, T Krishnadas, S Osman, E Lee, M Chan, A Tajudin, L Do, T Goncalves, A Reynier, P Zhang, H Bourne, R Goh, D Broadway, D Husain, R Negi, A Su, D Ho, C Blanco, A Leung, C Wong, T Yakub, A Liu, Y Nongpiur, M Han, J Hon, D Shantha, B Zhao, B Sang, J Zhang, N Sato, R Yoshii, K Panda-Jonas, S Ashley Koch, A Herndon, L Moroi, S Challa, P Foo, J Bei, J Zeng, Y Simmons, C Bich Chau, T Sharmila, P Chew, M Lim, B Tam, P Chua, E Ng, X Yong, V Chong, Y Meah, W Vijayan, S Seongsoo, S Xu, W Teo, Y Cooke Bailey, J Kang, J Haines, J Cheng, C Saw, S Tai, E Richards, J Ritch, R Gaasterland, D Pasquale, L Liu, J Jonas, J Milea, D George, R Al-Obeidan, S Mori, K Macgregor, S Hewitt, A Girkin, C Zhang, M Sundaresan, P Vijaya, L Mackey, D Wong, T Craig, J Sun, X Kinoshita, S Wiggs, J Khor, C Yang, Z Pang, C Wang, N Hauser, M Tashiro, K Aung, T Vithana, E |
| author_sort | Li, Z |
| collection | OXFORD |
| description | Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10(-33)), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10(-8)). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis. |
| first_indexed | 2024-03-07T02:36:39Z |
| format | Journal article |
| id | oxford-uuid:a901f0b8-14a9-47bc-ae3b-04674cb869bf |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:36:39Z |
| publishDate | 2015 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:a901f0b8-14a9-47bc-ae3b-04674cb869bf2022-03-27T03:06:03ZA common variant near TGFBR3 is associated with primary open angle glaucomaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a901f0b8-14a9-47bc-ae3b-04674cb869bfEnglishSymplectic Elements at OxfordOxford University Press2015Li, ZAllingham, RNakano, MJia, LChen, YIkeda, YMani, BChen, LKee, CGarway-Heath, DSripriya, SFuse, NAbu-Amero, KHuang, CNamburi, PBurdon, KPerera, SGharahkhani, PLin, YUeno, MOzaki, MMizoguchi, TKrishnadas, SOsman, ELee, MChan, ATajudin, LDo, TGoncalves, AReynier, PZhang, HBourne, RGoh, DBroadway, DHusain, RNegi, ASu, DHo, CBlanco, ALeung, CWong, TYakub, ALiu, YNongpiur, MHan, JHon, DShantha, BZhao, BSang, JZhang, NSato, RYoshii, KPanda-Jonas, SAshley Koch, AHerndon, LMoroi, SChalla, PFoo, JBei, JZeng, YSimmons, CBich Chau, TSharmila, PChew, MLim, BTam, PChua, ENg, XYong, VChong, YMeah, WVijayan, SSeongsoo, SXu, WTeo, YCooke Bailey, JKang, JHaines, JCheng, CSaw, STai, ERichards, JRitch, RGaasterland, DPasquale, LLiu, JJonas, JMilea, DGeorge, RAl-Obeidan, SMori, KMacgregor, SHewitt, AGirkin, CZhang, MSundaresan, PVijaya, LMackey, DWong, TCraig, JSun, XKinoshita, SWiggs, JKhor, CYang, ZPang, CWang, NHauser, MTashiro, KAung, TVithana, EPrimary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10(-33)), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10(-8)). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis. |
| spellingShingle | Li, Z Allingham, R Nakano, M Jia, L Chen, Y Ikeda, Y Mani, B Chen, L Kee, C Garway-Heath, D Sripriya, S Fuse, N Abu-Amero, K Huang, C Namburi, P Burdon, K Perera, S Gharahkhani, P Lin, Y Ueno, M Ozaki, M Mizoguchi, T Krishnadas, S Osman, E Lee, M Chan, A Tajudin, L Do, T Goncalves, A Reynier, P Zhang, H Bourne, R Goh, D Broadway, D Husain, R Negi, A Su, D Ho, C Blanco, A Leung, C Wong, T Yakub, A Liu, Y Nongpiur, M Han, J Hon, D Shantha, B Zhao, B Sang, J Zhang, N Sato, R Yoshii, K Panda-Jonas, S Ashley Koch, A Herndon, L Moroi, S Challa, P Foo, J Bei, J Zeng, Y Simmons, C Bich Chau, T Sharmila, P Chew, M Lim, B Tam, P Chua, E Ng, X Yong, V Chong, Y Meah, W Vijayan, S Seongsoo, S Xu, W Teo, Y Cooke Bailey, J Kang, J Haines, J Cheng, C Saw, S Tai, E Richards, J Ritch, R Gaasterland, D Pasquale, L Liu, J Jonas, J Milea, D George, R Al-Obeidan, S Mori, K Macgregor, S Hewitt, A Girkin, C Zhang, M Sundaresan, P Vijaya, L Mackey, D Wong, T Craig, J Sun, X Kinoshita, S Wiggs, J Khor, C Yang, Z Pang, C Wang, N Hauser, M Tashiro, K Aung, T Vithana, E A common variant near TGFBR3 is associated with primary open angle glaucoma |
| title | A common variant near TGFBR3 is associated with primary open angle glaucoma |
| title_full | A common variant near TGFBR3 is associated with primary open angle glaucoma |
| title_fullStr | A common variant near TGFBR3 is associated with primary open angle glaucoma |
| title_full_unstemmed | A common variant near TGFBR3 is associated with primary open angle glaucoma |
| title_short | A common variant near TGFBR3 is associated with primary open angle glaucoma |
| title_sort | common variant near tgfbr3 is associated with primary open angle glaucoma |
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commonvariantneartgfbr3isassociatedwithprimaryopenangleglaucoma AT vithanae commonvariantneartgfbr3isassociatedwithprimaryopenangleglaucoma |