CD4 T cell responses to a variant antigen of the malaria parasite Plasmodium falciparum, erythrocyte membrane protein-1, in individuals living in malaria-endemic areas.
Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a variant antigen on the surface of malaria-infected red blood cells. Antibody responses to PfEMP-1 correlate with immunity, and, therefore, PfEMP-1 may be a good candidate for a malaria vaccine. However, the specificity of CD4 T cell...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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| _version_ | 1797087533245399040 |
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| author | Allsopp, C Sanni, L Reubsaet, L Ndungu, F Newbold, C Mwangi, T Marsh, K Langhorne, J |
| author_facet | Allsopp, C Sanni, L Reubsaet, L Ndungu, F Newbold, C Mwangi, T Marsh, K Langhorne, J |
| author_sort | Allsopp, C |
| collection | OXFORD |
| description | Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a variant antigen on the surface of malaria-infected red blood cells. Antibody responses to PfEMP-1 correlate with immunity, and, therefore, PfEMP-1 may be a good candidate for a malaria vaccine. However, the specificity of CD4 T cells required for a protective variant-specific antibody response is not known. We have measured the CD4 T cell response to 3 different regions that are relatively homologous among different PfEMP-1 variants. The response to the cysteine-rich interdomain region was unusual in that the majority of donors, whether malaria exposed or not, had positive CD4 T cell, interleukin-10, and interferon-gamma responses. The CD4 T cell response to the exon 2 and duffy binding-like domain proteins was significantly greater in malaria-exposed donors than in unexposed Europeans, which suggests that these regions contain peptides recognized by T cells, which thus may be useful as components of a vaccine. |
| first_indexed | 2024-03-07T02:36:58Z |
| format | Journal article |
| id | oxford-uuid:a91e381a-61cf-4f4c-b5a3-3dde14a511b4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:36:58Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:a91e381a-61cf-4f4c-b5a3-3dde14a511b42022-03-27T03:06:14ZCD4 T cell responses to a variant antigen of the malaria parasite Plasmodium falciparum, erythrocyte membrane protein-1, in individuals living in malaria-endemic areas.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a91e381a-61cf-4f4c-b5a3-3dde14a511b4EnglishSymplectic Elements at Oxford2002Allsopp, CSanni, LReubsaet, LNdungu, FNewbold, CMwangi, TMarsh, KLanghorne, JPlasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a variant antigen on the surface of malaria-infected red blood cells. Antibody responses to PfEMP-1 correlate with immunity, and, therefore, PfEMP-1 may be a good candidate for a malaria vaccine. However, the specificity of CD4 T cells required for a protective variant-specific antibody response is not known. We have measured the CD4 T cell response to 3 different regions that are relatively homologous among different PfEMP-1 variants. The response to the cysteine-rich interdomain region was unusual in that the majority of donors, whether malaria exposed or not, had positive CD4 T cell, interleukin-10, and interferon-gamma responses. The CD4 T cell response to the exon 2 and duffy binding-like domain proteins was significantly greater in malaria-exposed donors than in unexposed Europeans, which suggests that these regions contain peptides recognized by T cells, which thus may be useful as components of a vaccine. |
| spellingShingle | Allsopp, C Sanni, L Reubsaet, L Ndungu, F Newbold, C Mwangi, T Marsh, K Langhorne, J CD4 T cell responses to a variant antigen of the malaria parasite Plasmodium falciparum, erythrocyte membrane protein-1, in individuals living in malaria-endemic areas. |
| title | CD4 T cell responses to a variant antigen of the malaria parasite Plasmodium falciparum, erythrocyte membrane protein-1, in individuals living in malaria-endemic areas. |
| title_full | CD4 T cell responses to a variant antigen of the malaria parasite Plasmodium falciparum, erythrocyte membrane protein-1, in individuals living in malaria-endemic areas. |
| title_fullStr | CD4 T cell responses to a variant antigen of the malaria parasite Plasmodium falciparum, erythrocyte membrane protein-1, in individuals living in malaria-endemic areas. |
| title_full_unstemmed | CD4 T cell responses to a variant antigen of the malaria parasite Plasmodium falciparum, erythrocyte membrane protein-1, in individuals living in malaria-endemic areas. |
| title_short | CD4 T cell responses to a variant antigen of the malaria parasite Plasmodium falciparum, erythrocyte membrane protein-1, in individuals living in malaria-endemic areas. |
| title_sort | cd4 t cell responses to a variant antigen of the malaria parasite plasmodium falciparum erythrocyte membrane protein 1 in individuals living in malaria endemic areas |
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