Docking study and biological evaluation of pyrrolidine-based iminosugars as pharmacological chaperones for Gaucher disease

Docking study and biological evaluation of pyrrolidine-based iminosugars as pharmacological chaperones for Gaucher disease

We report on the synthesis and biological evaluation of a series of α-1-C-alkylated 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) derivatives as pharmacological chaperones for Gaucher disease. The parent compound, DAB, did not show inhibition of human β-glucocerebrosidase but showed moderate intestinal α...

書誌詳細
主要な著者:	Kato, A, Nakagome, I, Sato, K, Yamamoto, A, Adachi, I, Nash, R, Fleet, G, Natori, Y, Watanabe, Y, Imahori, T, Yoshimura, Y, Takahata, H, Hirono, S
フォーマット:	Journal article
言語:	English
出版事項:	Royal Society of Chemistry 2016

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