Body mass index and breast cancer survival: a Mendelian randomization analysis
<strong>Background</strong> There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal...
| Главные авторы: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
Oxford University Press
2017
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| _version_ | 1826290014426759168 |
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| author | Guo, Q Burgess, S Turman, C Bolla, MK Wang, Q Lush, M Abraham, J Aittomäki, K Andrulis, IL Apicella, C Arndt, V Barrdahl, M Benitez, J Berg, CD Blomqvist, C Bojesen, SE Bonanni, B Brand, JS Brenner, H Broeks, A Burwinkel, B Caldas, C Campa, D Canzian, F Chang-Claude, J Chanock, SJ Chin, S-F Couch, FJ Cox, A Cross, SS Cybulski, C Czene, K Darabi, H Devilee, P Diver, WR Dunning, AM Earl, HM Eccles, DM Ekici, AB Eriksson, M Evans, DG Fasching, PA Figueroa, J Flesch-Janys, D Flyger, H Gapstur, SM Gaudet, MM Giles, GG Glendon, G Grip, M Gronwald, J Haeberle, L Haiman, CA Hall, P Hamann, U Hankinson, S Hartikainen, JM Hein, A Hiller, L Hogervorst, FB Holleczek, B Hooning, MJ Hoover, RN Humphreys, K Hunter, DJ Hüsing, A Jakubowska, A Jukkola-Vuorinen, A Kaaks, R Kabisch, M Kataja, V Kconfab/Aocs Investigators, Knight, JA Koppert, LB Kosma, V-M Kristensen, VN Lambrechts, D Le Marchand, L Li, J Lindblom, A Lindström, S Lissowska, J Lubinski, J Machiela, MJ Mannermaa, A Manoukian, S Margolin, S Marme, F Martens, JWM McLean, C Menéndez, P Milne, RL Mulligan, A Muranen, TA Nevanlinna, H Neven, P Nielsen, SF Nordestgaard, BG Olson, JE Perez, JIA Peterlongo, P Phillips, K-A Poole, CJ Pylkäs, K Radice, P Rahman, N Rüdiger, T Rudolph, A Sawyer, EJ Schumacher, F Seibold, P Seynaeve, C Shah, M Smeets, A Southey, MC Tollenaar, RAEM Tomlinson, I Tsimiklis, H Ulmer, H-U Vachon, C Van Den Ouweland, AMW Veer, LJ Wildiers, H Willett, W Winqvist, R Zamora, MP Chenevix-Trench, G Dörk, T Easton, DF García-Closas, M Kraft, P Hopper, JL Zheng, W Schmidt, MK Pharoah, PDP |
| author_facet | Guo, Q Burgess, S Turman, C Bolla, MK Wang, Q Lush, M Abraham, J Aittomäki, K Andrulis, IL Apicella, C Arndt, V Barrdahl, M Benitez, J Berg, CD Blomqvist, C Bojesen, SE Bonanni, B Brand, JS Brenner, H Broeks, A Burwinkel, B Caldas, C Campa, D Canzian, F Chang-Claude, J Chanock, SJ Chin, S-F Couch, FJ Cox, A Cross, SS Cybulski, C Czene, K Darabi, H Devilee, P Diver, WR Dunning, AM Earl, HM Eccles, DM Ekici, AB Eriksson, M Evans, DG Fasching, PA Figueroa, J Flesch-Janys, D Flyger, H Gapstur, SM Gaudet, MM Giles, GG Glendon, G Grip, M Gronwald, J Haeberle, L Haiman, CA Hall, P Hamann, U Hankinson, S Hartikainen, JM Hein, A Hiller, L Hogervorst, FB Holleczek, B Hooning, MJ Hoover, RN Humphreys, K Hunter, DJ Hüsing, A Jakubowska, A Jukkola-Vuorinen, A Kaaks, R Kabisch, M Kataja, V Kconfab/Aocs Investigators, Knight, JA Koppert, LB Kosma, V-M Kristensen, VN Lambrechts, D Le Marchand, L Li, J Lindblom, A Lindström, S Lissowska, J Lubinski, J Machiela, MJ Mannermaa, A Manoukian, S Margolin, S Marme, F Martens, JWM McLean, C Menéndez, P Milne, RL Mulligan, A Muranen, TA Nevanlinna, H Neven, P Nielsen, SF Nordestgaard, BG Olson, JE Perez, JIA Peterlongo, P Phillips, K-A Poole, CJ Pylkäs, K Radice, P Rahman, N Rüdiger, T Rudolph, A Sawyer, EJ Schumacher, F Seibold, P Seynaeve, C Shah, M Smeets, A Southey, MC Tollenaar, RAEM Tomlinson, I Tsimiklis, H Ulmer, H-U Vachon, C Van Den Ouweland, AMW Veer, LJ Wildiers, H Willett, W Winqvist, R Zamora, MP Chenevix-Trench, G Dörk, T Easton, DF García-Closas, M Kraft, P Hopper, JL Zheng, W Schmidt, MK Pharoah, PDP |
| author_sort | Guo, Q |
| collection | OXFORD |
| description | <strong>Background</strong> There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer. <br/><br/> <strong>Methods</strong> We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry. We created a BMI genetic risk score (GRS) based on genotypes at 94 known BMI-associated genetic variants. Association between the BMI genetic score and breast cancer survival was analysed by Cox regression for each study separately. Study-specific hazard ratios were pooled using fixed-effect meta-analysis. <br/><br/> <strong>Results</strong> BMI genetic score was found to be associated with reduced breast cancer-specific survival for estrogen receptor (ER)-positive cases [hazard ratio (HR) = 1.11, per one-unit increment of GRS, 95% confidence interval (CI) 1.01–1.22, P = 0.03). We observed no association for ER-negative cases (HR = 1.00, per one-unit increment of GRS, 95% CI 0.89–1.13, P = 0.95). <br/><br/> <strong>Conclusions</strong> Our findings suggest a causal effect of increased BMI on reduced breast cancer survival for ER-positive breast cancer. There is no evidence of a causal effect of higher BMI on survival for ER-negative breast cancer cases. |
| first_indexed | 2024-03-07T02:37:42Z |
| format | Journal article |
| id | oxford-uuid:a957e65d-0a17-4e6f-85e1-af1a146d95cc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:37:42Z |
| publishDate | 2017 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:a957e65d-0a17-4e6f-85e1-af1a146d95cc2022-03-27T03:08:18ZBody mass index and breast cancer survival: a Mendelian randomization analysisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a957e65d-0a17-4e6f-85e1-af1a146d95ccEnglishSymplectic Elements at OxfordOxford University Press2017Guo, QBurgess, STurman, CBolla, MKWang, QLush, MAbraham, JAittomäki, KAndrulis, ILApicella, CArndt, VBarrdahl, MBenitez, JBerg, CDBlomqvist, CBojesen, SEBonanni, BBrand, JSBrenner, HBroeks, ABurwinkel, BCaldas, CCampa, DCanzian, FChang-Claude, JChanock, SJChin, S-FCouch, FJCox, ACross, SSCybulski, CCzene, KDarabi, HDevilee, PDiver, WRDunning, AMEarl, HMEccles, DMEkici, ABEriksson, MEvans, DGFasching, PAFigueroa, JFlesch-Janys, DFlyger, HGapstur, SMGaudet, MMGiles, GGGlendon, GGrip, MGronwald, JHaeberle, LHaiman, CAHall, PHamann, UHankinson, SHartikainen, JMHein, AHiller, LHogervorst, FBHolleczek, BHooning, MJHoover, RNHumphreys, KHunter, DJHüsing, AJakubowska, AJukkola-Vuorinen, AKaaks, RKabisch, MKataja, VKconfab/Aocs Investigators,Knight, JAKoppert, LBKosma, V-MKristensen, VNLambrechts, DLe Marchand, LLi, JLindblom, ALindström, SLissowska, JLubinski, JMachiela, MJMannermaa, AManoukian, SMargolin, SMarme, FMartens, JWMMcLean, CMenéndez, PMilne, RLMulligan, AMuranen, TANevanlinna, HNeven, PNielsen, SFNordestgaard, BGOlson, JEPerez, JIAPeterlongo, PPhillips, K-APoole, CJPylkäs, KRadice, PRahman, NRüdiger, TRudolph, ASawyer, EJSchumacher, FSeibold, PSeynaeve, CShah, MSmeets, ASouthey, MCTollenaar, RAEMTomlinson, ITsimiklis, HUlmer, H-UVachon, CVan Den Ouweland, AMWVeer, LJWildiers, HWillett, WWinqvist, RZamora, MPChenevix-Trench, GDörk, TEaston, DFGarcía-Closas, MKraft, PHopper, JLZheng, WSchmidt, MKPharoah, PDP<strong>Background</strong> There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer. <br/><br/> <strong>Methods</strong> We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry. We created a BMI genetic risk score (GRS) based on genotypes at 94 known BMI-associated genetic variants. Association between the BMI genetic score and breast cancer survival was analysed by Cox regression for each study separately. Study-specific hazard ratios were pooled using fixed-effect meta-analysis. <br/><br/> <strong>Results</strong> BMI genetic score was found to be associated with reduced breast cancer-specific survival for estrogen receptor (ER)-positive cases [hazard ratio (HR) = 1.11, per one-unit increment of GRS, 95% confidence interval (CI) 1.01–1.22, P = 0.03). We observed no association for ER-negative cases (HR = 1.00, per one-unit increment of GRS, 95% CI 0.89–1.13, P = 0.95). <br/><br/> <strong>Conclusions</strong> Our findings suggest a causal effect of increased BMI on reduced breast cancer survival for ER-positive breast cancer. There is no evidence of a causal effect of higher BMI on survival for ER-negative breast cancer cases. |
| spellingShingle | Guo, Q Burgess, S Turman, C Bolla, MK Wang, Q Lush, M Abraham, J Aittomäki, K Andrulis, IL Apicella, C Arndt, V Barrdahl, M Benitez, J Berg, CD Blomqvist, C Bojesen, SE Bonanni, B Brand, JS Brenner, H Broeks, A Burwinkel, B Caldas, C Campa, D Canzian, F Chang-Claude, J Chanock, SJ Chin, S-F Couch, FJ Cox, A Cross, SS Cybulski, C Czene, K Darabi, H Devilee, P Diver, WR Dunning, AM Earl, HM Eccles, DM Ekici, AB Eriksson, M Evans, DG Fasching, PA Figueroa, J Flesch-Janys, D Flyger, H Gapstur, SM Gaudet, MM Giles, GG Glendon, G Grip, M Gronwald, J Haeberle, L Haiman, CA Hall, P Hamann, U Hankinson, S Hartikainen, JM Hein, A Hiller, L Hogervorst, FB Holleczek, B Hooning, MJ Hoover, RN Humphreys, K Hunter, DJ Hüsing, A Jakubowska, A Jukkola-Vuorinen, A Kaaks, R Kabisch, M Kataja, V Kconfab/Aocs Investigators, Knight, JA Koppert, LB Kosma, V-M Kristensen, VN Lambrechts, D Le Marchand, L Li, J Lindblom, A Lindström, S Lissowska, J Lubinski, J Machiela, MJ Mannermaa, A Manoukian, S Margolin, S Marme, F Martens, JWM McLean, C Menéndez, P Milne, RL Mulligan, A Muranen, TA Nevanlinna, H Neven, P Nielsen, SF Nordestgaard, BG Olson, JE Perez, JIA Peterlongo, P Phillips, K-A Poole, CJ Pylkäs, K Radice, P Rahman, N Rüdiger, T Rudolph, A Sawyer, EJ Schumacher, F Seibold, P Seynaeve, C Shah, M Smeets, A Southey, MC Tollenaar, RAEM Tomlinson, I Tsimiklis, H Ulmer, H-U Vachon, C Van Den Ouweland, AMW Veer, LJ Wildiers, H Willett, W Winqvist, R Zamora, MP Chenevix-Trench, G Dörk, T Easton, DF García-Closas, M Kraft, P Hopper, JL Zheng, W Schmidt, MK Pharoah, PDP Body mass index and breast cancer survival: a Mendelian randomization analysis |
| title | Body mass index and breast cancer survival: a Mendelian randomization analysis |
| title_full | Body mass index and breast cancer survival: a Mendelian randomization analysis |
| title_fullStr | Body mass index and breast cancer survival: a Mendelian randomization analysis |
| title_full_unstemmed | Body mass index and breast cancer survival: a Mendelian randomization analysis |
| title_short | Body mass index and breast cancer survival: a Mendelian randomization analysis |
| title_sort | body mass index and breast cancer survival a mendelian randomization analysis |
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