Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21

The 40-fold increase in childhood megakaryocyte-erythroid and B-cell leukemia in Down syndrome implicates trisomy 21 (T21) in perturbing fetal hematopoiesis. Here, we show that compared with primary disomic controls, primary T21 fetal liver (FL) hematopoietic stem cells (HSC) and megakaryocyte-eryth...

Full description

Bibliographic Details
Main Authors: Roy, A, Cowan, G, Mead, AJ, Filippi, S, Bohn, G, Chaidos, A, Tunstall, O, Chan, JKY, Choolani, M, Bennett, P, Kumar, S, Atkinson, D, Wyatt-Ashmead, J, Hu, M, Stumpf, MPH, Goudevenou, K, O'Connor, D, Chou, ST, Weiss, MJ, Karadimitris, A, Jacobsen, SE, Vyas, P, Roberts, I
Format: Journal article
Language:English
Published: National Academy of Sciences 2012

Similar Items

Similar Items